Jonas Jerebko added 17 points and a season-high nine rebounds for the Pistons, who ended an eight-game home skid.
The Bulls led by as many as 11 points in the first quarter but Detroit gradually caught up and took the lead in the second after starting the period on a 12-4 run.
Carlos Boozer had 21 points and 10 rebounds for the postseason-bound Bulls, who are fighting to secure the fourth seed in the Eastern Conference. Nate Robinson added 18 points and Jimmy Butler scored 14 as Chicago's two-game winning streak ended.
The Pistons took a 50-46 lead to intermission and pushed it to as many as 10 in the third quarter. Knight scored a dozen points in the period. Detroit scored the first four points of the fourth and never let the Bulls get closer than 10 points the rest of the night.
Rodney Stuckey had 14 points and rookie Andre Drummond added 10 rebounds for Detroit.
Luol Deng, the Bulls' leading scorer and the NBA's leader in minutes per game, missed the game with a sore hip. Coach Tom Thibodeau said the decision to bench him was "precautionary."
Chicago's Joakim Noah, who missed eight games with an injured right foot, and Marco Belinelli, who was out seven with an abdominal strain, each returned Sunday night.
The Bulls were aiming to match the franchise record for consecutive victories over an opponent, which also was against the Pistons. Michael Jordan's 1990s teams won 19 in a row against Detroit.
The Pistons treated home fans to their first win since the All-Star break. They hadn't won at the Palace of Auburn Hills since Feb. 13.
Notes: Pistons point guard Jose Calderon, who had started all 28 games since Detroit acquired him in a Jan. 30 trade, missed the game with a right triceps strain. . Chicago's last loss to the Pistons was Dec. 23, 2008.
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