Aaron Craft added 14 points, Amadeo Della Valle had 13 and Sam Thompson 12. Amir Williams finished with eight points and five of the Buckeyes' 11 blocks.
Jesse Hardin led the Cavaliers with 18 points.
Ohio State led 49-26 at halftime, making 19 of 24 free throws while the Cavaliers were 1 of 2.
The Buckeyes return four starters from the team that went 29-8 and reached the regional finals in the NCAA tournament, losing only scoring leader Deshaun Thomas.
Ohio State opens the regular season at home against Morgan State on Nov. 9.
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