Monta Ellis added 13 points and nine assists for the Mavericks, who nearly squandered a 23-point second-half lead.
Indiana forward Danny Granger left the game with 4:05 left in the first quarter with a strained left calf and did not return.
He missed most of last season after having surgery on his left knee. He made 1 of 4 shots and scored three points before leaving.
Luis Scola and Orlando Johnson each scored 14 points for the Pacers.
Four of Indiana's regular starters sat out. Roy Hibbert, David West and George Hill rested and Paul George has bronchitis.
Dallas' Vince Carter rested and Jose Calderon (strained left hamstring), Devin Harris (left foot surgery) and Shane Larkin (fractured right ankle) also did not play.
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