| 
            
			 After showing his hand and pressuring his smaller competitor on 
			Monday by disclosing two bid approaches, both of which were 
			rebuffed, Pfizer CEO Ian Read has until May 26 to "put up or shut 
			up" under UK takeover rules. 
 			Importantly, after a jump in Pfizer shares, Read knows he has the 
			backing of many of his own shareholders, while the threat of a 
			counterbid does not appear imminent.
 			Read and his team will be using the time available to consider how 
			they can sweeten an offer made in January worth 58.8 billion pounds 
			($98.8 billion), or 46.61 pounds a share, comprising 30 percent cash 
			and 70 percent shares.
 			AstraZeneca said that offer fell "very significantly" short and it 
			specifically flagged the small cash component, which would leave 
			investors exposed to the risks faced by Pfizer in executing an 
			ambitious mega-merger.
 			So far, the British group has refused to talk to Pfizer — but it has 
			not ruled out discussions altogether and one person close to the 
			company said the cash component of any fresh offer would be key in 
			determining if there was engagement in future. 			
 
 			Cash is uppermost in the minds of AstraZeneca shareholders, too.
 			"For it to move forward from here, they (Pfizer) need to find a way 
			of getting Astra management engaged and that feels like it needs a 
			specific value being applied to the group, and it needs the cash 
			element to be higher," said Alastair Gunn of Jupiter Fund Management 
			<JUP.L>, which is a top-20 investor in AstraZeneca.
 			Analysts at Jefferies believe a deal could get done with Pfizer 
			offering a 50/50 split between cash and shares at a price of at 
			least 50 pounds a share.
 			Several investors contacted by Reuters confirmed they were looking 
			for 50 pounds a share or more, with Neil Veitch of SVM Asset 
			Management predicting an agreed deal somewhere between 52 and 53 
			pounds.
 			Because a key goal of the planned takeover is to get the tax 
			advantages of re-domiciling the enlarged group in Britain, there is 
			a limit to how much cash Pfizer can offer, since at least 20 percent 
			of its shareholders are required to be UK-based.
 			"We estimate Pfizer will need to issue a minimum of around $55 
			billion in shares to comfortably meet this requirement," Jefferies 
			said.
 			Based on the original 30 percent cash element, Moody's analyst 
			Michael Levesque said Pfizer could fund the whole of the cash 
			portion with offshore funds.
 			Pushing the cash element to 50 percent, however, would require 
			taking on some incremental debt. 
            
            [to top of second column] | 
 
			SORIOT CANVASSES INVESTORS
 AstraZeneca CEO Pascal Soriot, whose efforts to revive the firm's 
			drug pipeline have proved a key draw for Pfizer, will now be 
			canvassing the views of shareholders as a "priority", with machinery 
			in place for meetings with big and small investors, two people close 
			to the company said.
 
 			Soriot and chairman Leif Johansson will also be weighing strategic 
			alternatives for the drugmaker, including the potential spin-off of 
			non-core therapy areas like infection and neuroscience, as well as 
			possible acquisitions.
 			But "white knight" counterbidders ready to take on Pfizer are likely 
			to be thin on the ground — not least because few other companies 
			would enjoy the same cost and tax benefits from acquiring 
			AstraZeneca as Pfizer.
 			Amgen <AMGN.O> is one player for whom an AstraZeneca deal might make 
			sense, since the two companies are co-developing a number of drugs, 
			but a person familiar with the U.S. biotech firm said on Tuesday it 
			was not interested in entering the fray.
 			French drugmaker Sanofi <SASY.PA> is another company with the heft 
			and M&A experience to consider intervening, yet its CEO Chris 
			Viehbacher said on Tuesday he planned to stick to smaller bolt-on 
			acquisitions.
 			GlaxoSmithKline <GSK.L>, the British company with arguably the 
			greatest potential to extract synergies from buying AstraZeneca, has 
			meanwhile said for several years it is not interested in large 
			deals.
 			($1 = 0.5950 British pounds)
 			(Additional reporting by Anjuli Davies; 
editing by Mark Potter) 
			[© 2014 Thomson Reuters. All rights 
				reserved.] Copyright 2014 Reuters. All rights reserved. This material may not be published, 
			broadcast, rewritten or redistributed.
 
			
			
			 |