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 Painkillers and antidepressants were most strongly tied to a greater
likelihood of being injured in a fall, the study of 64,000 Swedes
over age 65 found. Severe injuries were significantly more common
with 11 out of the 20 medications studied.
“Medications that affect the central nervous system; hypnotics,
sedatives, analgesics and antidepressants,” were of particular
concern, said Jette Moller from the Karolinska Institute in
Stockholm, the study’s senior author.
Some of the added risk may stem from the conditions the drugs are
prescribed to treat, researchers note. But given the large and
growing population of seniors, the study team says links between the
drugs and fall injuries should be taken into account when doctors
prescribe these popular medications.
More than 40 million people in the U.S. are over 65 years old, an
age group that tends to take a large number of prescription drugs.
Fully one third take eight or more medications daily, according to
the National Center for Biotechnology Information.
Falls are a leading cause of disability and death among seniors and
researchers increasingly suspect that prescription medications play
an important role in fall injuries.
Moller and her colleagues looked at falls among people taking any of
the 20 medications most commonly prescribed to seniors in Sweden,
several of which were already known to be fall-inducing drugs. The
researchers analyzed data on nearly seven million Swedish people
over age 65 and identified 64,399 cases of falling injuries that led
to hospitalization.
After adjusting for the number of medications a person was taking,
the researchers found men and women taking opioid painkillers as
well as men taking antidepressants were more than twice as likely to
have a fall injury as seniors who were not taking those drugs. Women
taking antidepressants were 75 percent more likely to have a fall
injury.
Drugs for ulcers and GERD, calcium, vitamin B12 and some non-opioid
painkillers were also linked to a 15 to 75 percent greater risk of
fall injuries.
Estrogens and certain heart medications were not linked to fall
injuries. “None of the medications affecting the cardiovascular
system have such an effect,” Möller noted. In fact, these
medications showed a slightly protective effect. The only exception
was diuretics given in high doses.
The study cannot prove that medications caused falls in all cases,
and for drugs that have not previously been linked to fall injuries
– including anticlotting agents, drugs for peptic ulcers and vitamin
B12 – the researchers think the underlying conditions the drugs are
prescribed to treat may be to blame.
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Differentiating between falls caused by disorders and those caused
by medications may be difficult, according to Dr. Johan Fastbom, a
professor at the Aging Research Center at the Karolinska Institute
who was not involved in the study.
He recommends “paying attention to other symptoms caused by the
drugs.” Among these, he listed vertigo, dizziness, drowsiness,
psychomotor impairment, muscular weakness and cognitive impairment.
Fastbom told Reuters Health in an email that if elderly people
taking these medications “experience any or several (more
problematic) of these symptoms, they should consider if the risk may
be greater than the benefit.”
Further studies will likely take into consideration the different
dosage levels of the medications, as these were found to vary
considerably and differed between men and women.
In the future, researchers will also likely consider the potential
interactions between medications, including those taken over the
counter, which may also cause the elderly to fall more frequently.
Although many medications may greatly improve the quality of life of
elderly people, Moller thinks the risk of falling and being
seriously injured must be taken into account.
“Patients should be able to make informed decisions about the
medication they take. Fall injuries are a serious threat to the
health and well-being of older people in their own right and this
needs to be acknowledged,” she told Reuters Health in an email.
Fastbom advises elderly people who are concerned about this risk to
“ask their doctor to do a drug utilization review, with focus on
fall-inducing drugs.”
SOURCE: http://bit.ly/1AbFq0O
The European Journal of Public Health, online July 31, 2014.
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