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			 The London-listed company, which makes expensive medicines to treat 
			rare diseases, fought off four earlier bids from AbbVie until the 
			U.S. firm raised its price to 52.48 pounds per share - made up of 
			24.44 pounds in cash and 0.8960 new AbbVie shares. 
			 
			Chicago-based AbbVie is buying Shire to cut both its U.S. tax bill 
			and its reliance on arthritis drug Humira, the world's top selling 
			medicine which loses U.S. patent protection in 2016. AbbVie, which 
			generates nearly 60 percent of its revenue from Humira, had until 
			Friday to announce a firm offer for Shire, extend the deadline or 
			walk away under UK takeover rules. 
			 
			It now plans to create a company listed in New York, incorporated in 
			Jersey, the Channel Islands, and tax-domiciled in Britain, which 
			will pay an effective tax of about 13 percent by 2016, sharply lower 
			than its current rate of about 22 percent, making the deal one of 
			the biggest driven by the tactic known as tax inversion. 
			 
			America's Pfizer Inc tried to pull off the same trick earlier this 
			year when it made a bid for Britain's AstraZeneca plc though its 
			$118 billion deal was rejected. 
			  
            
			  
			 
			Calls for political action to stop tax inversion deals are growing 
			in the United States. U.S. Treasury Secretary Jacob Lew urged 
			Congress this week to take steps to discourage companies moving 
			their tax domiciles aboard, saying "economic patriotism" was needed. 
			 
			Dick Durbin, the No. 2 Democrat in the U.S. Senate, criticized 
			AbbVie for moving after using taxpayer-supported medical research to 
			become one of the United States’s most profitable companies. 
			 
			"It was our government’s patent office which protected their 
			discoveries and guarded their right to make a profit,” said Durbin 
			of Illinois. “Now AbbVie is ‘moving’ to an Irish island to escape 
			paying the U.S. taxes it owes.” 
			 
			AbbVie's Chairman and Chief Executive Officer Richard Gonzalez said 
			he thought the debate would be more appropriately shifted to tax 
			reform and making companies more competitive in the global economy. 
			U.S. companies cannot move overseas earnings back into the country 
			for acquisitions or investment without losing part of it to the 
			taxman. 
			 
			"Companies like ours need access to our global cash flows to be able 
			to make investments all around the world, but specifically to be 
			able to make investments in the United States, and today we at a 
			disadvantage versus many of our foreign competitors," he said. 
			 
			However, he added, tax cutting was not the main objective of the 
			Shire deal. 
			 
			"It's not the primary rationale for this," he told analysts on a 
			conference call, explaining that the combined group would have 
			leadership positions in immunology, rare diseases, neuroscience, and 
			metabolic and liver diseases, as well as a best-in-class product 
			development platform, a stronger pipeline and better R&D 
			capabilities. 
			 
			
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			The merged group will also have more firepower for acquisitions, he 
			said, particularly to bolster the rare disease business, the 
			foundations of which were built on acquisitions by Shire. 
			 
			RAISED GUIDANCE 
			 
			Shire's board had said on Monday it was ready to recommend the 
			higher offer from AbbVie, signaling the end of a lengthy courtship. 
			 
			AbbVie's agreed price represents a premium of about 53 percent to 
			Shire's share price on May 2, the last business day before AbbVie's 
			first offer, which was rebuffed by Shire. 
			 
			Shares in Shire, which will own about 25 percent of the combined 
			group, closed 3.9 percent higher at 49.96 pounds, while AbbVie was 
			up 2.1 percent to $54.65 at 1615 GMT. 
			 
			Gonzalez said Shire Chief Executive Officer Flemming Ornskov, whose 
			tenure at the drugmaker was marked by earnings upgrade after 
			earnings upgrade, would stay on, initially to help with integration 
			and then to head a dedicated rare disease division. 
			 
			Separately, Shire raised its earnings guidance for the year on 
			Friday, to low-to-mid 30 percent growth, from mid-to-high 20 percent 
			growth. The company, which also produces hyperactivity drug Vyvanse, 
			reported record revenue of $1.5 billion for its second quarter and a 
			42 percent jump in its preferred earnings measure of non-GAAP 
			adjusted earnings per ADS to $2.67. 
			 
			Shire was advised by Goldman Sachs, Morgan Stanley, Deutsche Bank, 
			Evercore and Citi, while AbbVie was advised by J.P.Morgan.($1 = 
			0.5847 British Pounds) 
			 
			(Editing by Sophie Walker and Lisa Shumaker) 
			[© 2014 Thomson Reuters. All rights 
			reserved.] Copyright 
			2014 Reuters. All rights reserved. This material may not be 
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