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 In a small pilot study, the researchers used electronic
cigarettes, or e-cigarettes, to mimic the behavioral aspects of
smoking tobacco cigarettes, and say future studies could help
scientists understand why smoking is so addictive.
E-cigarettes use battery-powered cartridges to produce a
nicotine-laced vapor to inhale -- hence the new term "vaping".
Their use has rocketed in recent years, but there is fierce debate
about the risks and benefits. Some public health experts say they
could help millions quit tobacco cigarettes, while others argue they
could "normalize" the habit and lure children into smoking.
While that argument rages, tobacco kills some 6 million people a
year, and the World Health Organization estimates that could rise
beyond 8 million by 2030.
 Matt Wall, an imaging scientist at Imperial College London who led
the study using e-cigarettes, said he was not aiming to pass
judgment on their rights or wrongs, but to use them to dig deeper
into smoking addiction.
The fact that other forms of nicotine replacement therapy, such as
patches or gum, have had only limited success in getting hardened
smokers to quit suggests they are hooked on more than just nicotine,
he noted.
"There's something unique about the drug (nicotine) and the delivery
system -- the smoking -- combined which makes it really, really
addictive," he told Reuters.
And by analyzing the brains of people "smoking" or "vaping"
e-cigarettes, scientists can study the brain effects of what he
called the "the behavioral and sensory repertoire of smoking".
Until now, it was impossible to monitor these effects with
conventional cigarettes due to the difficulty of having people smoke
in the confined space of an MRI scanner.
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But because e-cigarettes produce water vapor and do not burn, Wall's
team could record brain activity with each drag.
Wall said the study was not large enough to draw any firm
conclusions yet, although it did show interesting activity in brain
areas linked to reward and addiction, and in areas involved in
perception of taste and smell.
"E-cigarettes ... provide a very good simulation of traditional
smoking (and) we have shown that using e-cigarettes with fMRI is an
excellent paradigm for direct evaluation of the effects of smoking
on human neurophysiology," he said.
The plan now is to conduct larger studies using "vapers".
Wall's findings were due to be presented on Tuesday at the Global
Addiction Conference in Rio de Janeiro.
(Editing by Kevin Liffey)
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