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			 San Francisco (6-4) climbed into second place in the NFC West, 
			tied with the Seattle Seahawks behind first-place Arizona. The 
			Giants fell to 3-7, and pushing their losing streak to five games. 
 It was the first multi-interception game since Week 2 for Manning, 
			who finished 21 of 41 for 276 yards. He also threw five 
			interceptions in a loss to the Seahawks in 2012.
 
 "I didn't expect this. I didn't plan on it," Manning said. "I have 
			to make better decisions, better throws. They're all on me. It's no 
			one's else's fault. I have to protect the ball and can't afford to 
			turn it over, especially in field goal range."
 
 The Giants, who hadn't scored on their opening drive in 20 games, 
			put an end to that streak thanks to a turnover by 49ers running back 
			Frank Gore, who lost the handle on the ball at the Giants 16-yard 
			line.
 
 
			 
			Manning connected twice with receiver Rueben Randle for 38 yards, 
			and running back Rashad Jennings, in his first game back from a knee 
			injury suffered in Week 5, ran twice for six yards. The Giants 
			capped the scoring drive when Manning found tight end Larry Donnell 
			for a 19-yard touchdown and the 7-0 lead.
 
 The maligned Giants defense, which last week allowed 350 rushing 
			yards and which has been outscored 136-62 over the team's four-game 
			losing streak, actually kept this one close, holding the 49ers to 
			just three first-half field goals of 31, 37, and 44 yards by kicker 
			Phil Dawson, who gave his team a 9-7 lead at the half.
 
 The 49ers scored their only touchdown of the game in the third 
			quarter when quarterback Colin Kaepernick, who finished 15 of 29 for 
			193 yards, connected with receiver Michael Crabtree on a 48-yard 
			touchdown pass to increase their lead 16-10.
 
 "It was an outstanding throw and a great route and then Michael 
			really hit the yards after reception and was playing football," said 
			head coach Jim Harbaugh.
 
 After Josh Brown's 43-yard field goal closed the 49ers' lead to 
			16-10, the Giants recovered an onside kick.
 
 But any momentum gained from that change of possession was lost on 
			third-and-9 as Manning's third interception gave the 49ers the ball 
			back, and safety Eric Reid returned it 51 yards.
 
 The Giants had a final opportunity to take the lead in the fourth 
			quarter. Manning connected with receiver Odell Beckham Jr., who 
			finished with six receptions for 93 yards, on a spectacular 37-yard 
			reception to set up first-and-goal on the 49ers' 4-yard line.
 
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			Manning threw three consecutive fade passes that fell incomplete 
			before being picked off for the fifth time in the game on the 
			fourth-down desperation heave.
 "The four shots from the 4-yard line -- it was inexcusable that we 
			didn't score," said Giants head coach Tom Coughlin, who noted that 
			the 49ers defense, which came into this week's game having allowed 
			opposing offenses to score touchdowns on 69.6 percent of their red 
			zone possessions, was 30th in red zone defense. "In hindsight we 
			should have run the ball, but we've done a good job in the green 
			zone and the tight green zone, but this particular day, the 
			frustration to be standing here 17-16 instead we're standing here 
			with a loss."
 
 Last week, the 49ers topped the Saints in overtime 27-24. With the 
			win against the Giants this week, the 49ers are home against the 
			Washington Redskins.
 
 "We'll enjoy this one; this will be a happy flight home," Harbaugh 
			said. "I feel really good. Our team played with a lot of heart and a 
			lot of fight."
 
 NOTES: For the first time since 1998, when Jim Fassel was the team's 
			head coach, New York has a 3-7 record in its first 10 regular-season 
			games. That year, the Giants went on to win five of their final six 
			games to finish 8-8. ... The 49ers improved to 21-9 in road games 
			played under head coach Jim Harbaugh, who took over in 2011. With a 
			win percentage of .700, the 49ers remain first in the NFL in road 
			wins since the 2011 season. ... The 49ers also improved to 3-0 
			against the NFC East this season, and have outscored three of the 
			four NFC East teams played -- Dallas, Philadelphia and the Giants -- 
			by a 60-48 margin. ... Giants head coach Tom Coughlin fell to 5-2 
			against the 49ers and 15-14 overall against the NFC West. He was 3-4 
			against the NFC West as head coach to Jacksonville (1995-2002) and 
			is now 12-10 against that division as head coach of the Giants.
 
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