Array Biopharma melanoma drug succeeds in late-stage study

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[December 16, 2015]  (Reuters) - Array BioPharma Inc said its experimental drug helped patients with a form of melanoma live longer without their cancer progressing, in an ongoing late-stage study.

The company's stock jumped about 24 percent before the opening bell on Wednesday.

Data showed that patients with advanced NRAS-mutant melanoma treated with the drug, binimetinib, lived for a median of 2.8 months before their disease worsened, compared with 1.5 months for patients treated with the chemotherapy dacarbazine.

Nearly 74,000 new cases of melanoma and nearly 10,000 deaths from the disease are projected for 2015, according to Array. NRAS mutations occur in about 15 to 20 percent of metastatic melanoma patients. On average, those with the stubborn mutation live an average of 8.5 months once diagnosed.

 

Array's "NEMO" trial, which consists of 402 patients, is one of many studies the drug is being evaluated in. Binimetinib is also being tested in separate late-stage studies in patients with BRAF-mutant melanoma and ovarian cancer.

The company said on Wednesday said it plans to submit an application to market binimetinib to treat NRAS-mutant melanoma during the first half of 2016.

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The stock closed at $3.83 on the Nasdaq on Tuesday.

(Reporting by Natalie Grover in Bengaluru; Editing by Shounak Dasgupta)

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