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 Farmers at the site in Laronxe, about 100 km (60 miles) from
Strasbourg, are growing plants in an unconventional way so they can
"milk" them for rare molecules that could be used in medicines,
cosmetics and agrochemicals.
Several major companies, including German chemicals group BASF and
French cosmetics maker Chanel, have teamed up with Plant Advanced
Technologies (PAT) in the hope of securing privileged access to the
so-called biomolecules it extracts through the use of a patented
technique.
"Our job is to develop vegetal platforms that will produce very rare
biomolecules on an industrial scale," Jean-Paul Fevre, co-founder of
PAT, and a former head of research with French drugmaker Sanofi,
told Reuters.
The 10-year-old French firm tests around 100 plant species every
year. They are grown using aeroponics, a soil-free culture system
that allow roots to interact with a mist containing various
nutrients to allow the plants to grow.
The biomolecules PAT hunts are those produced when plants' defenses
are triggered, which it has found to be most useful for commercial
applications.
 In a process similar to vaccination, farmers spray on liquids
containing traces of a bacteria, insect or fungus that attack the
plant - to activate its defenses - before submerging the roots in a
solvent to extract the desired molecules. The operation is repeated
several times a year.
"Plants generate defense molecules naturally," said Frederic
Bourgaud, a PAT vice president. "We ensure they produce as many of
them as possible," he said.
PAT is not alone in seeking to extract commercially promising
ingredients from plants - the field includes firms such as Italy's
Indena and France's Pierre Fabre and Naturex. But it is the only
company to use the "milking" technique to harvest molecules.
PESTICIDES, DRUGS
BASF, the world's largest chemicals company by sales, sealed a deal
with PAT in May under which it gains exclusive access to tests
involving molecules that could be used in agriculture, such as
biological pesticides. In return, the German group provides PAT with
research teams and industrial know-how.
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"What makes PAT stand out is their ability to target the right
plants. On a blind search, you may end up testing some 150,000
molecules before identifying the right one but I would say they have
a 30 percent rate," said Jean-Marc Petat, BASF France's head of
sustainable development, referring to their rate of success for
finding potentially useful molecules.
The global biopesticide and synthetic pesticide market will grow
from $54.8 billion in 2013 to $83.7 billion by 2019, according to
research firm BCC. Biopesticides on their own accounted for around
$3.6 billion of the market last year and that figure could reach
$6.9 billion by 2019, it said.
Chanel was the first company to sign a production agreement with
PAT, in 2012, teaming up to manufacture a new anti-aging cream made
out of an edulis, a plant native to South Africa, that is now on the
market.
PAT says it has 28 promising molecules in its pipeline and that some
of its products could be used to design medicines to fight diseases
such as cancer and Alzheimer's.
The company, listed on the European small and midcap Alternext index
and owned by its three co-founders, aims to become profitable by the
end of 2016.
The firm also aims to become one of the first groups to extract
proteins from genetically modified carnivorous plants. The proteins
could be used by the health sector to manufacture cheaper and safer
insulin or growth hormones, it says.
(Writing by Matthias Blamont; Editing by Andrew Callus and Pravin
Char)
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