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Rose won the 2004
Nobel Prize in chemistry, along with Israel Institute of
Technology researchers Aaron Ciechanover and Avram Hershko, for
research into how cells break down and dispose of old and
damaged proteins in plants and animals.
"These findings of the 'kiss-of-death' mechanisms inside cells
proved revolutionary, transforming the field of cell biology and
ultimately fostering a new understanding of the molecular
activity present in cancer and other diseases," the university
said.
Errors in the degradation process can lead to diseases such as
cervical cancer and cystic fibrosis, the Royal Swedish Academy
of Sciences said at the time it made the Nobel award.
Rose died in his sleep in Deerfield, Massachusetts, his family
told the university, where he worked during the latter part of
his career.
Born in Brooklyn, New York, in 1926, Rose earned a doctoral
degree at the University of Chicago in 1952. He spent most of
his career at the Fox Chase Center in Philadelphia.
In 1997, Rose took up a special research position with the
department of physiology and biophysics at the University of
California, Irvine.
(Reporting by Brendan O'Brien; Editing by Clarence Fernandez)
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