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 “This may mean that the higher cardiovascular risk seen among
post-menopausal women could be related to changes in that time
before menopause and less so to the changes after menopause has
occurred,” said lead study author Dr. Mark DeBoer, a researcher at
University of Virginia School of Medicine in Charlottesville.
While the reasons for this are unclear, the findings suggest that
women may need to pay especially close attention to cardiovascular
risk factors in the years leading up to menopause and consider
lifestyle changes like improved diet and exercise habits that can
make problems like diabetes and heart disease less likely, DeBoer
added by email.
Menopause typically happens between ages 45 and 55. As the ovaries
curb production of estrogen and progesterone, menstruation stops,
and women can experience symptoms such as hot flashes, night sweats
and vaginal dryness.
Certain treatments for menopause symptoms that contain man-made
versions of the hormones estrogen and progestin have also been
linked to an increase risk of heart attack and stroke.
Previous research has also linked menopause to an increased risk of
what’s known as metabolic syndrome, a constellation of conditions
that increase the risk of heart disease, diabetes and stroke.
Obesity, inactivity and a history of smoking appear to make these
problems more likely.
For the current study, researchers examined data on 1,470 white and
African-American women participating in a national study of the
causes and health effects of hardening of the arteries.
All of the women went through menopause during the ten-year study
period.
Researchers focused on five things that contribute to metabolic
syndrome: expanding waist circumference, elevated fats in the flood,
declines in so-called “good” HDL cholesterol, spikes in blood
pressure and increased levels of sugar in the blood.
After taking into account whether women used hormone-replacement
therapy, researchers still found bigger changes in triglycerides
(fats in the blood), cholesterol and glucose (blood sugar) before
menopause than afterwards.
For white women, waist size spiked more after menopause, however.
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African-American women experienced larger increases in blood
pressure after menopause than before, the researchers report in the
Journal of the American Heart Association.
One limitation of the study is that researchers defined the timing
of menopause based on whether women said they had a menstrual period
in the previous two years, the authors note. Menopause is commonly
diagnosed after women cease menstruation for one year, which means
the study may have categorized some women as going through this
transition who had already completed it.
Researchers also lacked data on hormone levels for individual women,
even though these can fluctuate and influence the risk for metabolic
problems, said Dr. Robert Eckel, of the University of Colorado
Anschutz Medical Campus in Aurora.
Not all types of hormone-replacement therapy carry the same risks,
and the study also didn’t account for the way hormones were
administered, Eckel, who wasn’t involved in the study, said by
email.
“Cardiovascular disease screening remains important for all adults
including men and women,” Eckel said. “Perhaps the frequency of
evaluation should be more emphasized in this important peri-menopausal
interval (between ages 45-55) in women - more science needed here.”
SOURCE: http://bit.ly/1f4U4k9 Journal of the American Heart
Association, released August 3, 2016.
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