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 In the first six months after starting testosterone, men have a 63
percent higher risk of clots in the legs and lungs than they did
before beginning treatment, the study found.
While the absolute risk of a clot, known as a venous thromboembolism,
is low and diminishes over time, men should still discuss it with
their doctors, said lead study author Dr. Carlos Martinez of the
Institute for Epidemiology, Statistics and Informatics GmbH in
Frankfurt, Germany.
"This observational study suggests an increased risk of venous
thromboembolism soon after the start of testosterone use," Martinez
said by email. "The risk declines after more than six months'
treatment."
Although the increased risks are temporary, and still relatively low
in absolute terms, the researchers warn that failure to investigate
the timing and duration of testosterone use in previous studies
could have masked this association.
For the current study, researchers examined data on about 19,000
patients with blood clots and more than 900,000 similar men without
a history of clots collected from 2001 to 2013 in the U.K.
For the men treated with testosterone, researchers looked at three
different groups: patients in current treatment, men with recent
treatment not currently taking testosterone, and men who had not
taken testosterone in the previous two years. Current treatment was
subdivided into duration of more or less than six months.
Compared with men who hadn't used testosterone, current users had a
25 percent higher risk of clots, researchers report in The BMJ.
After six months of treatment, the risk returned to levels similar
to what men had before starting testosterone.
The study is observational and can't prove testosterone causes clots
or that stopping treatment would reduce the risk of clots, the
authors note.
Testosterone levels decline gradually over time, leading to symptoms
such as decreased libido, sexual dysfunction, decreased bone mineral
density, mood disorders, reduced muscle mass and fatigue. Most of
these symptoms can also come from other causes such as diabetes,
high blood pressure, heart disease and thyroid disorders.
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Millions of men worldwide have taken testosterone to address these
symptoms.
Some previous studies suggest a possible relationship between low
testosterone and hardening of the arteries, heart disease, and blood
clots, said Dr. Joao Zambon, a researcher at Wake Forest University
in Winston-Salem, North Carolina who wasn't involved in the study.
"It is unclear if this is a causal relationship or a concomitant
event," Zambon added by email.
"Despite all the benefits in terms of well-being, quality of life
and symptom improvement, there are still many controversies and
questions without answer in terms of testosterone replacement
therapy," Zambon said.
This makes regular check-ups essential.
"For patients with symptoms and low testosterone levels and for
those who have already been using testosterone replacement therapy,
it is highly recommended that they get a regular follow-up with a
specialist to avoid any unexpected events," Zambon said.
SOURCE: http://bit.ly/2gcnuPb The BMJ, online November 30, 2016.
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