Codeine has been prescribed for decades for both purposes, despite
mounting evidence that it doesn’t always work and sometimes causes
serious or potentially fatal side effects, doctors argue in a
statement from the American Academy of Pediatrics.
“We firmly believe that there is never a reason to use codeine,”
said the lead author of the statement, Dr. Joseph Tobias of Ohio
State University and Nationwide Children’s Hospital in Columbus, in
email to Reuters Health.
Codeine has been linked to life-threatening or fatal respiratory
problems in children for more than a decade, Tobias and colleagues
note in the statement published in the journal Pediatrics.
A recent review by the U.S. Food and Drug Administration (FDA) of
potentially dangerous side effects in kids using codeine identified
64 cases of severe slowed breathing rates and 24 deaths related to
the drug, including 21 deaths in kids under 12.
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Respiratory issues often developed after children had surgery to
remove their adenoids and tonsils, a procedure done to address
obstructed breathing during sleep or treat acute or chronic
tonsillitis.
Generally, the life-threatening events and deaths associated with
codeine were found in relatively young kids who received a
combination of acetaminophen and codeine after surgery.
Some children with undiagnosed nighttime breathing problems may also
have respiratory problems after taking codeine, and obesity may
increase the risk of this occurring.
As doctors weigh the risks of prescribing codeine to children, they
also need to consider the instances when there’s not enough evidence
that the drug works, according to the AAP statement.
There’s little proof codeine is effective for kids’ coughs, and
mounting evidence suggests that some children may not respond to
treatment for pain.
Part of the problem is the way codeine is processed by the body.
It’s converted by the liver into morphine that can ease pain. But
genetic differences can trigger the liver to create too little or
not enough morphine. Too little means the medicine doesn’t work; too
much means there could be dangerous or even fatal slowdowns in
breathing.
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Despite mounting safety concerns and questions about whether codeine
works, the drug is still widely prescribed and available without a
prescription over-the-counter in 28 states and the District of
Columbia, according to the statement.
The FDA ordered what’s known as a “black box” warning – its
strongest – on codeine in 2013 cautioning doctors not to give the
drug to kids having surgery to remove their adenoids or tonsils.
Many major children’s hospitals across the U.S. have already advised
doctors to stop prescribing codeine, noted Dr. Constance Houck, a
researcher at Boston Children’s Hospital and an author of the
statement.
“This statement is meant to insure that all pediatricians, pediatric
subspecialists and pediatric surgical specialists (including
dentists) are aware of the concerns with codeine and recognize that,
for the safety of their patients, they should switch to another oral
opioid,” Houck said.
“Opioids should never be prescribed for cough and there are other
oral opioids such as oxycodone and hydrocodone that are available
for use in children and these should be prescribed instead,” Houck
added by email.
Parents shouldn’t assume codeine is ok to give kids without seeing a
doctor first, said Dr. Alan Woolf, a researcher at Harvard Medical
School who wasn’t involved in the AAP statement.
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“They should ask what the alternative pain relievers are,” Woolf
said by email. “Parents should not give their child codeine for
coughs or colds.”
SOURCE: http://bit.ly/2dbwW51 Pediatrics, online September 19, 2016.
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