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 Some previous research has linked parental smoking to an increased
risk of childhood leukemia, but with less consistent results for
mothers than for fathers. The current study is the first to link
smoking by both parents to specific genetic changes in tumor cells
of children with acute lymphoblastic leukemia (ALL), said lead study
author Adam de Smith, a researcher at the University of California
San Francisco’s Helen Diller Family Comprehensive Cancer Center.
“Another way of looking at this is that we are seeing evidence of
the toxic effects of tobacco smoke in the genes of the leukemia
cell, a molecular type of forensic pathology,” de Smith said by
email.
“These deletions are not inherited from parents but are acquired in
the child’s immune cells, so we think the more important windows of
tobacco exposure are during pregnancy and after birth,” he added.
Acute lymphoblastic leukemia is a cancer that starts from the early
version of white blood cells called lymphocytes in the bone marrow,
the soft inner part of the bones where new blood cells are made.
With this type of cancer, the bone marrow makes irregular
lymphocytes with errors known as deletions in their DNA, causing
unchecked growth that crowds out healthy cells.
Each year about 5,970 new cases of ALL are diagnosed in the U.S. and
about 1,440 people die from the disease, according to the American
Cancer Society. The risk of developing ALL is highest in children
under age 5, though the majority of the deaths occur with adult
cases.
For the current study, researchers examined data on pre-treatment
tumor samples from 559 ALL patients in a study of childhood leukemia
cases in California. They wanted to see if any of the eight genes
that are often deleted in ALL patients were missing in the tumor
samples, and whether any of these deletions were associated with
parental smoking habits.
Roughly two thirds of the tumor samples contained at least one of
these deletions, the study in Cancer Research found.
Deletions were considerably more common in children whose mothers
had smoked during pregnancy and after birth. For each five
cigarettes smoked daily during pregnancy, there was a 22 percent
increase in the number of deletions; and for each five cigarettes
smoked daily during breastfeeding, there was a 74 percent increase
in the number of deletions.
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Smoking of five cigarettes daily by the mother or father before
conception also was associated with a 7 percent to 8 percent
increase in the number of deletions.
Boys were found to be more sensitive to the effects of maternal
smoking, including smoking that occurred pre-conception. This could
be explained by the fact that male fetuses grow more rapidly,
leading to increased vulnerability of developing lymphocytes to
toxins that cause genetic damage, the authors note.
One limitation of the study is that researchers don’t know when
genetic deletions occurred relative to the development of leukemia.
Researchers also relied on parents to accurately recall and report
their smoking habits in questionnaires, making it possible the
timing or amount of tobacco exposure might be incorrect in some
cases.
Still, the findings should reinforce how important it is for parents
to quit or cut back tobacco use, said Dr. Marte Reigstad, a
researcher at Oslo University Hospital in Norway who wasn’t involved
in the study.
“The best thing to do to reduce risk to a minimum is to cut out
smoking altogether,” Reigstad, who wasn’t involved in the study,
said by email.
For people who grew up with parents that smoked, it’s important to
understand that tobacco isn’t the only thing that causes cancer,
Reigstad added.
“Living healthy lives can also reduce cancer risk, especially
concerning exercise and keeping a healthy body weight,” Reigstad
said.
SOURCE: http://bit.ly/2ngHrw9 Cancer Research, online March 22,
2017.
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