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 Adding to optimism is the success of antiretrovirals in preventing
infection - an approach known as pre-exposure prophylaxis (PrEP) -
as well as growing hopes for an eventual "functional" cure that may
keep the virus at bay without drugs.
Researchers believe such advances are necessary to stay ahead of a
virus that can all too often develop resistance to medicines,
despite the use since 1996 of three- or four-drug combinations that
mean HIV/AIDS is no longer a death sentence.
"New products are needed. The Achilles heel for us is drug
resistance because the virus is incredibly quick to mutate,"
Linda-Gail Bekker, deputy director of the Desmond Tutu HIV Centre in
South Africa, said.
Bekker is also president of the International AIDS Society, which
organized the conference in Paris where the latest clinical results
were presented.
The race for better and more convenient medicines has made HIV a
rich battleground for drug companies such as Gilead Sciences and
GlaxoSmithKline, which generate billions of dollars from modern
therapies.
Both companies garnered fresh ammunition to boost their products in
Paris.
New clinical data confirmed Gilead's new drug bictegravir, given
with older antiretrovirals, was as good as GSK's established
dolutegravir and had a similar side effect profile. Gilead filed the
new cocktail for regulatory approval in June.
Both bictegravir and dolutegravir are so-called integrase
inhibitors, a type of medicine that has proved extremely effective
at blocking HIV.
GSK, meanwhile, unveiled results of a 96-week study with a
long-acting two-drug injection given every four or eight weeks using
another integrase inhibitor, cabotegravir, that showed it worked as
well - and perhaps better - than standard daily pills.
For GSK, two-drug cocktails represent the future of HIV treatment,
especially for the growing number of older patients who are more
vulnerable to side effects from taking multiple medicines.
It hopes to win approval for its first dual therapy - a tablet
containing dolutegravir - later this year.
GSK's long-acting injection is further off but it offers an option
for people who don't want daily pills, which some experts think
might be 10 to 20 percent of the market. GSK also faces a rival in
Merck & Co, which is working on an even longer-lasting drug that
could one day be used as an implant.
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David Redfern, chairman of GSK's majority-owned ViiV Healthcare HIV
business, believes one thing is clear: competition is set to
intensify.
"The battle will play through from next year, but we feel in a
strong position to defend the franchise that we have built up," he
told Reuters.
Gilead's clinical research head Andrew Cheng said the rival
combinations were very comparable and there would now be a shift in
treatment to the newer, more effective therapies.
VACCINE NEEDED
Ultimately, many experts believe a vaccine will be needed to shut
down the threat from HIV, although decades of efforts to develop one
have so far ended in disappointment.
Scientists are not giving up, however, and a new approach pioneered
by Johnson & Johnson, working with U.S. government experts and
others, is set to enter large Phase IIb trials later this year.
The decision to push ahead with a so-called prime-boost vaccine in a
trial involving thousands of patients in Africa comes after
promising data presented in Paris on Monday, showing the
two-component shot generated a good immune response.
It also follows another large-scale trial already underway in
Africa, which uses a modified version of a vaccine that showed a
modest 31 percent reduction in infections in Thailand in 2009.
In both cases, researchers are looking for reductions in infection
rates of at least 50 percent, and hopefully more.
With 36.7 million people around the world infected with HIV and more
than half of them getting treatment that is expected to last for
life, J&J Chief Scientific Officer Paul Stoffels sees parallel
advances in drugs and vaccines as essential.
"We should not claim victory yet in HIV," he said. "The people who
are infected today will need therapy for the next 30 to 50 years, so
the science of treatment has to evolve - and the science of
prevention has to evolve as well to stop the pool of patients
growing."
(Reporting by Ben Hirschler. Editing by Jane Merriman)
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