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 The research will focus on glioblastoma, the most common form of
brain cancer, which has a five-year survival rate of barely 5
percent.
Zika causes severe disability in babies by attacking developing stem
cells in the brain - but in adults, whose brains are fully formed,
it often causes no more than mild flu-like symptoms.
In glioblastoma, the cancer cells are similar to those in the
developing brain, suggesting that the virus could be used to target
them while sparing normal adult brain tissue.
Experts say existing treatments have to be given at low doses to
avoid damaging healthy tissue.
Researchers led by Harry Bulstrode at Cambridge University will use
tumor cells in the lab and in mice to assess Zika's potential.
The mosquito-borne virus has spread to more than 60 countries and
territories in a global outbreak that was first identified in Brazil
in 2015.
"Zika virus infection in babies and children is a major global
health concern, and the focus has been to discover more about the
virus to find new possible treatments," Bulstrode said in a
statement.
"We're taking a different approach, and want to use these new
insights to see if the virus can be unleashed against one of the
hardest-to-treat cancers ...
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"We hope to show that the Zika virus can slow down brain tumor
growth in tests in the lab," Bulstrode added. "If we can learn
lessons from Zika's ability to cross the blood-brain barrier and
target brain stem cells selectively, we could be holding the key to
future treatments."
(Editing by Louise Ireland and Kevin Liffey)
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