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 The study involved roughly 163,000 patients who started chemotherapy
or targeted therapies for a new cancer diagnosis in Ontario from
2007 to 2014. Overall, 10,880 were hospitalized with serious kidney
damage or for dialysis.
This translated into a cumulative acute kidney injury rate of 9.3
percent, the study found.
People with advanced tumors were 41 percent more likely to have
acute kidney injuries than patients with early-stage cancer.
Compared to the group as a whole, individuals who already had
chronic kidney disease were 80 percent more likely to be
hospitalized for a kidney injury, and people with diabetes had a 43
percent greater chance.
"Patients should be aware that kidney injury can result during
cancer treatment - both due to cancer itself and the drugs used to
treat it," said lead study author Dr. Abhijat Kitchlu of the
University of Toronto.
Many medicines that treat tumors are removed from the body by the
kidneys and can damage certain cells within the kidneys, Kitchlu
said by email.
"It may be possible to reduce the risk of acute kidney injury by
maintaining good hydration and in some cases, avoiding other drugs
that can increase risk to the kidneys," Kitchlu added. Medications
that can damage the kidneys include ibuprofen and other
non-steroidal anti-inflammatory drugs(NSAIDs), certain blood
pressure medicines, and diuretics. In fact, in the study, older
patients taking water pills or certain heart medications were also
at higher risk for serious kidney problems.
"Patients should seek early medical attention when concerned about
dehydration or infection, as the symptoms related to kidney injury
(decreased urine output, swelling, nausea, fatigue or confusion) may
only occur after the kidneys have been damaged," Kitchlu advised.
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In the current study, patients were more than twice as likely to
develop acute kidney problems within the first 90 days of starting
cancer treatment than they were later on, researchers report in the
Journal of the National Cancer Institute.
Patients who are already at high risk of kidney damage because of
health problems like diabetes may be able to take cancer drugs that
are less likely to damage the kidneys, said Leah Siskind, of the
University of Louisville Medical School in Kentucky.
"However, these less nephrotoxic chemotherapeutics are often less
effective at reducing tumor burden," Siskind, who wasn't involved in
the study, said by email.
Patients at high risk for kidney damage should discuss alternative
drugs or doses with their physicians to see if they can treat tumors
in a way that minimizes their chance of kidney injury, advised Dr.
Laura Cosmai of San Carlo Borromeo Hospital in Milan, Italy.
And all patients should be on the alert for potential warning signs
of kidney problems like dehydration, nausea, vomiting or diarrhea,
Cosmai, who wasn't involved in the study, said by email.
Vigilance is important because "cancer patients who develop acute
kidney injury during treatment do have reduced survival odds,"
Cosmai said.
SOURCE: http://bit.ly/2S86P2g Journal of the National Cancer
Institute, online November 13, 2018.
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