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 But many of the companies immediately pushed back, saying the FDA
list of drugmakers may be out of date and that some of the drugs
included on it already have generic competitors.
The FDA said the list contained all of the inquiries about drugs it
had received from generic drugmakers since 2005. It said companies
generally do not inform it if they have made samples available after
a generic developer has reached out to the agency.
Releasing the list of drugmakers, which includes Celgene Corp <CELG.O>,
Johnson & Johnson <JNJ.N>, Gilead Sciences <GILD.O> and Novartis AG
<NOVN.S>, is part of the Trump administration's efforts to pressure
companies to lower drug prices.
Last week, U.S. President Donald Trump unveiled a "blueprint" aimed
at doing that, but critics have said the proposals did not do nearly
enough to substantially decrease the cost of drugs for consumers.
Shares of drugmakers rose on Friday after Trump's speech.
The agency said companies on the list may be using FDA safety
regulations and other tactics to deny access to their medicines from
generic drugmakers hoping to copy them.
Generic drugmakers may not be able to develop alternatives without
access to samples of branded products they intend to copy, the FDA
said.
"I want to be very clear: a path to securing samples of brand drugs
for the purpose of generic drug development should always be
available," FDA Commissioner Scott Gottlieb said in a statement.
Gottlieb, who has made faster approvals of cheaper generic medicines
a priority, said this should be true even in cases where there is
limited access to drugs for safety reasons.
The FDA is notifying the Federal Trade Commission, which can
investigate anti-competitive acts, of cases where drugmakers may be
blocking access to their products if there is no safety reason,
Gottlieb added.
The FDA said it had also heard of some drugmakers adopting tactics
to make it hard for generic companies to purchase branded drugs even
at a fair value in the open market.
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Industry lobby group Pharmaceutical Research and Manufacturers of
America (PhRMA) said it was concerned that the FDA list lacks
context and conflates a number of issues.
"It is important to differentiate between those products for which
FDA has received complaints as opposed to those products for which
it has received a request for a safety determination letter," PhRMA
said.
Celgene, for example, argued that the three of its products on the
FDA list all carry risk of significant side effects, including
severe birth defects.
"These therapies are subjected to rigorous safety controls that have
been developed by the company and approved by the FDA," Celgene said
in a statement. It noted that two of the three drugs already have
generic versions licensed to enter the market in coming years,
including multiple myeloma treatment Revlimid, by far the company's
biggest selling product.
A number of other companies said the drugs in question already had
generic competition. Roche <ROG.S>, which was listed for acne drug
Accutane, said it stopped making or selling the drug in the United
States in 2009.
RBC Capital Markets analyst Brian Abrahams said in a research note
that the effect of the FDA's list will likely be limited.
"Though such efforts maintain the public concern about biopharma's
role in high drug prices and potentially anti-competitive practices,
other than creating negative optics for these companies we see
minimal impact such a list will have on actual generic risk," he
said.
(Reporting by Michael Erman in New York; Additional reporting by
Tamara Mathias and Manas Mishra in Bengaluru; editing by Bill
Berkrot and Tom Brown)
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