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 The study team found that atrial fibrillation raises the overall
risk of developing dementia by 40 percent and the risk of vascular
and mixed dementias by nearly 90 percent. But people with AF who got
anti-clotting drugs were 60 percent less likely than those who
didn't get the drugs to develop dementia, according to the report in
Neurology.
"We found that people with atrial fibrillation may experience faster
decline in cognitive performance, such as thinking and memorizing
skills, and have a greater risk of dementia than those without
atrial fibrillation," said the study's lead author Mozhu Ding, a
doctoral candidate at the Aging Research Center of the Karolinska
Institute in Stockholm, Sweden.
"Notably we found that older patients with atrial fibrillation
taking blood thinners, which prevent clots from forming in the heart
and traveling to the brain, were less likely to develop dementia
than those who were not taking blood thinners," Ding said.
In atrial fibrillation, electrical signals in the heart muscle are
disturbed, causing the heart to quiver rather than contract
normally. As a result, blood doesn't move as well through the heart,
which can lead to formation of clots that can travel to the brain
and cause a stroke.
Many patients with atrial fibrillation are prescribed
anticoagulants, also known as blood thinners, that lengthen the time
it takes for clots to form in the blood.
To assess the connection between AF and dementia risk, Ding and her
colleagues followed 2,685 volunteers in the Swedish National Study
on Aging and Care for an average of six years. At the beginning of
the study, the volunteers, whose average age was 73, were examined
and interviewed, allowing researchers to collect a wealth of
lifestyle and medical data. All were free of dementia at the outset,
but 243 people, or 9 percent of the group, had atrial fibrillation.
Participants who were younger than 78 at the beginning of the study
were checked again after six years. Those who were 78 and older were
examined and interviewed once every three years. During the course
of the study, another 279 people developed atrial fibrillation. By
the end of the study, 300 participants had developed dementia.
Of the 2,163 volunteers without atrial fibrillation, 10 percent
developed dementia. Of the 522 with atrial fibrillation, 23 percent
developed dementia.
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The researchers also found that people with atrial fibrillation who
took blood thinners had a lower dementia risk than peers with AF who
were not on blood thinners. While 22 percent of AF patients who did
not take blood thinners developed dementia, just 11 percent of those
who did take the medication went on to develop dementia.
How could an irregular heartbeat lead to dementia?
"People with atrial fibrillation could experience massive or mini
strokes, which substantially increase the risk of dementia," Ding
said in an email. "It is also likely that atrial fibrillation lowers
the blood flow to the brain and results in brain ischemia, which in
turn hastens cognitive decline and eventually the onset of
dementia."
While blood thinners seem to lower the risk of dementia in patients
with atrial fibrillation, the medications do increase the risk of
bleeding, Ding said. "Therefore, in older people with atrial
fibrillation, the decision to start blood thinner therapy should be
individualized."
This is not the first study to suggest a link between atrial
fibrillation and dementia, said Dr. Eric Buchof the David Geffen
School of Medicine at the University of California, Los Angeles, who
wasn't involved in the study.
The new findings "could be considered as one more potential benefit
to blood thinners, whose role in stroke prevention in atrial
fibrillation patients is well established," Buch said in an email.
"Research from the same group presented at the Heart Rhythm annual
meeting in 2017 suggests that delayed initiation of blood thinners
was associated with an increased risk of developing dementia as
compared to patients starting blood thinners right away."
SOURCE: https://bit.ly/2A39SCo and https://bit.ly/2IPfzH1 Neurology,
online October 10, 2018.
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