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			 Overall, adolescents who used e-cigarettes before trying any other 
			tobacco products were more than four times as likely to be smoking 
			traditional cigarettes within a couple of years compared to those 
			who had never tried any type of vaping device or non-cigarette 
			tobacco products, the study team reports in JAMA Network Open. 
 "E-cigarettes may be a pathway to cigarette smoking, and a sizeable 
			one," said senior study author Andrew Stokes of the Boston 
			University School of Public Health.
 
 Overall, smoking rates have dropped significantly, Stokes said. 
			"That's been a real success story for public health and in that 
			context, it's pretty alarming that a new product has come on the 
			market potentially drawing a whole generation into using tobacco," 
			he added.
 
			
			 
			
 Stokes and his colleagues explored the influence of e-cigarettes 
			through the Population Assessment of Tobacco and Health Study 
			(PATH), a nationally-representative sample of kids aged 12 to 15 who 
			completed annual questionnaires between 2013 and 2016.
 
 Along with questions about vaping and smoking, the surveys asked 
			about kids' socioeconomic backgrounds and their attitudes about 
			smoking. They were also asked questions designed to illuminate how 
			prone they were toward risky behaviors and sensation-seeking.
 
 Those who reported using a tobacco product in the three years of 
			surveys were asked which of 12 products they had "tried first," 
			including traditional cigarettes, cigars, pipes, hookahs, chewing 
			tobacco, snus and e-cigarettes.
 
 Stokes and his colleagues focused on the 6,123 kids who said in the 
			first-wave survey that they had never used any tobacco product. By 
			the third survey, 6.1 percent of these kids reported smoking or 
			having tried traditional cigarettes.
 
 Among kids who had first tried e-cigarettes, just over 20 percent 
			had tried or were regularly smoking cigarettes by wave three, and 
			among kids who first tried other non-cigarette tobacco products, 
			more than 21 percent had tried or were smoking cigarettes. That 
			compares with just 4 percent of kids who had not used any type of 
			non-cigarette tobacco products.
 
			
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			Researchers calculated that the odds of trying traditional 
			cigarettes or becoming regular smokers were 4.09 times higher for 
			those who tried e-cigarettes first, and 3.84 times higher after 
			trying other non-cigarette tobacco products first.
 But for those kids considered to be at low risk for taking up 
			smoking – who had initially said they had no interest in smoking, 
			were risk averse and less likely to seek out new experiences - first 
			using e-cigarettes raised the risk of eventual smoking by 8.57 
			times. This added risk wasn't seen among first users of other 
			non-cigarette products.
 
 Stokes suspects that there are several reasons why kids who don't 
			see themselves ever smoking cigarettes might be open to vaping. 
			First, he said, many don't realize that nicotine is a highly 
			addictive substance. "And there is also the 'cool factor,'" he said. 
			"The flavors are very appealing and we know that they are 
			disproportionately appealing to youth, who are exposed to a lot of 
			marketing targeted to them on social media."
 
 The new findings are "pretty consistent with what we've seen before 
			in this area in terms of demonstrating that people who experiment 
			with electronic cigarettes, even if they swear at baseline that they 
			would never smoke regular cigarettes, are at much more risk of 
			transitioning to regular cigarettes," said Dr. Brian Primack, 
			director of the Center for Research on Media, Technology and Health 
			at the University of Pittsburgh in Pennsylvania.
 
 The new study "strengthens earlier findings in a couple of ways," 
			Primack said. "First, this is a very large and prestigious database 
			and that is important with an area as controversial as this. You 
			want to make sure your evidence is as strong as possible. The other 
			thing it does is show that the magnitude of risk is even higher for 
			those at low risk for using cigarettes. We've been seeing hints of 
			this all along. And this is particularly problematic for people who 
			probably would never have touched a cigarette to begin with."
 
 SOURCE: https://bit.ly/2MKNMJE JAMA Network Open, online February 1, 
			2019.
 
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