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			 The request came six days after U.S. District Judge Dan Polster in 
			Cleveland refused to recuse himself and said he had done nothing to 
			favor the state and local governments suing for damages, including 
			by encouraging settlements. 
 But the eight pharmacy chains and drug distributors told the 6th 
			U.S. Circuit Court of Appeals in Cincinnati that Polster has "lost 
			sight" of his responsibility to appear unbiased, including by 
			acknowledging a "personal mission" to address the opioid crisis.
 
 Polster oversees more than 2,300 of the roughly 2,600 lawsuits 
			brought by state, local and tribal governments, hospitals and other 
			entities seeking to hold the drug industry responsible for the toll 
			of opioid abuse.
 
 The scheduled Oct. 21 trial is the first in a federal court.
 
			
			 
			
 Ohio's Cuyahoga and Summit counties, the only plaintiffs, want $8 
			billion of damages, according to the eight companies.
 
 "The time for disqualification is now," the companies said.
 
 They added that removing Polster would help preserve "public 
			confidence in the integrity of the judicial system. That should be a 
			special imperative in this litigation, which is so much in the 
			public eye."
 
			
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			The companies include retailers CVS Health Corp, Rite Aid Corp, 
			Walgreens Boots Alliance Inc and Walmart Inc, and distributors 
			AmerisourceBergen Corp, Cardinal Health Inc, Henry Schein Inc and 
			McKesson Corp.
 Their disqualification request, originally made directly to Polster 
			on Sept. 14, followed several rulings against them.
 
 Legal experts have called the effort to remove Polster a long shot, 
			saying it is common for judges to encourage settlements and that 
			disqualifications are rare.
 
 Ohio, 13 other states and Washington, D.C. have separately asked the 
			appeals court to halt the upcoming trial, saying it undermines their 
			right to litigate on their own.
 
 Opioid addiction claimed roughly 400,000 lives in the United States 
			from 1999 to 2017, according to the U.S. Centers for Disease Control 
			and Prevention.
 
 (Reporting by Jonathan Stempel in New York; Editing by Cynthia 
			Osterman)
 
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