Brent was down 18 cents, or 0.4%, at $50.07 a barrel at 1242
GMT, after rising above $51 a barrel on Thursday to an
early-March high.
U.S. oil was down 12 cents, or 0.3%, at $46.66 a barrel, having
risen almost 3% in the previous session.
Promising vaccine trials have helped lift some gloom over record
increases in the number of new coronavirus infections and deaths
around the world.
Britain began inoculations this week and the United States could
start vaccinations as early as the coming weekend, while Canada
on Wednesday approved its first vaccine with initial shots due
from next week.
"The vaccine optimism ... seems to continue unscathed due to the
back-to-back approvals vaccines are getting and the
quicker-than-previously-thought rollout of the first campaigns
in key markets," Rystad Energy analyst Paola Rodriguez-Masiu
said.
Outside advisers for the U.S. Food and Drug Administration have
voted to endorse emergency use of Pfizer's vaccine, paving the
way for the agency to authorise its use to inoculate a nation
that has lost more than 285,000 lives to COVID-19.
A big jump in U.S. crude stockpiles last week served as a
reminder that there is still plenty of supply available, but it
was all but ignored as bulls ran through the market this week. [EIA/S]
"The long-awaited rollout of vaccination programmes provided
ample bullish fodder in the face of rising US oil inventories,"
brokerage PVM's Stephen Brennock said.
A fall in world shares as markets confronted the risk of Britain
leaving the European Union without a trade deal weighed on
sentiment.
"The probability of a no deal is higher than of a deal," an EU
official who declined to be identified quoted the head of the
European Commission Ursula von der Leyen as saying on Friday.
(Additional reporting by Aaron Sheldrick in Tokyo; Editing by
Robert Birsel and Mark Potter)
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