'Peak twins?' - Scientists say IVF means more being born now than ever before

[March 13, 2021]  By Kate Kelland

LONDON (Reuters) - More twins are being born now than ever before, largely due to rising use of in vitro fertilisation (IVF) and other assisted reproduction techniques, the first global study of human twinning has found.

With about 1.6 million twins born each year worldwide, the global twinning rate has risen by a third since the 1980s, to 12 per 1,000 deliveries from 9 per 1,000 around 30 years ago, the study found.

This might well be "peak twins", scientists behind the research said - particularly in high-income regions such as Europe and North America where there is now an emphasis on refining fertility treatments to minimise multiple births.

"We think we're actually at the peak," said Christiaan Monden, a professor at Britain's Oxford University who co-led the review. "This is likely to be an all-time high. The relative and absolute numbers of twins in the world are higher than they have ever been since the mid-twentieth century."

Monden's research team, whose findings were published on Friday in the journal Human Reproduction, analysed data on twinning rates for 165 countries between 2010 and 2015 and for 112 countries for the period 1980 to 1985.

They found a 71% rise in twinning rates in North America, as well as significant rises in many European countries and in Asia. For Asia overall, there was a 32% increase, they said, and only seven countries saw falls of more than 10% in twinning rates over the study period.

The researchers noted that rates of monozygotic or identical twins - born from the same egg - were barely changed, stable at about 4 per 1,000 deliveries worldwide.

More twins are being born now than ever before, largely due to rising use of in vitro fertilisation (IVF) and other assisted reproduction techniques, the first global study of human twinning has found.

This meant the vast majority of the increase in twinning rates was due to high numbers of dizygotic or non-identical twins - twins born from separate eggs.

This was especially true in Africa, Monden said, and is most likely to be due to genetic differences between African populations and other populations.

"Most twins you'll meet in Japan are identical twins," he said, "while most twins you'll meet in Africa are non-identical - and we think that's genetic."

While factors such as women choosing to start families later, greater use of contraception, and lower fertility rates might be playing some part in the increase in twinning rates, Monden said medically assisted reproduction techniques - which began in the 1970s - are the main drivers.

Such fertility treatments were originally available in wealthier regions, but spread to emerging economies in Asia and Latin America in the 1980s and 1990s, reaching the relatively richer parts of South Asia and Africa after 2000.

SOURCE: https://bit.ly/2NcUZa7 Human Reproduction, online March 12. 2021.

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