Three-times major winner Murray was set to face Djokovic for the
37th time in a highly anticipated clash on clay at the ATP Masters
1000 event in the Spanish capital.
"Unfortunately, Andy Murray is unable to take to the Manolo Santana
Stadium due to illness," organisers wrote on Twitter.
"Instead, Andrey Rublev and Daniel Evans will open the day's play on
centre court."
Former world number one Murray, who had earlier said he would skip
the claycourt season in order to protect his fitness, accepted a
late wildcard in Madrid and beat Dominic Thiem and Denis Shapovalov
in his opening two matches.
(Reporting by Dhruv Munjal in Bengaluru; editing by Clare Fallon)
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