Hospital officials said at least 147 people were wounded, with
many of them in critical condition.
Prime Minister Shebaz Sharif called the blast a suicide attack.
There were at least 260 people in the mosque, police official
Sikandar Khan added.
No one has claimed responsibility for the bombing, which ripped
through the mosque during noon prayers, causing a wall to
collapse on top of worshippers. The building is located inside a
highly fortified compound that includes the headquarters of the
provincial police force and a counter-terrorism department.
"We're getting that the terrorist was standing in the first
row," Defense Minister Khawaja Asif told Geo TV.
Footage from government broadcaster PTV showed police and
residents scrambling to remove debris from the blast site and
carrying wounded people on their shoulders.
The attack was the city's worst since March last year, when a
suicide bombing at a Shi'ite Muslim mosque during Friday prayers
killed at least 58 people and injured nearly 200. Islamic State
militants claimed responsibility for that bombing.
Peshwar, which sits at the edge of Pakistan's tribal districts
bordering Afghanistan, is frequently targeted by militant
groups, including the Pakistani Taliban.
The group, known as Tehreek-e-Taliban Pakistan (TTP) is an
umbrella of Sunni and sectarian Islamist groups that want to
overthrow the government and replace it with their own brand of
Islamic governance.
The TTP has stepped up attacks since it ended a so-called peace
deal last year with the Pakistani government, which was
facilitated by Afghan Taliban.
TTP has staged frequent attacks targeting police in the last few
months. In December, Islamist militants seized a
counter-terrorism centre in the northwestern and took hostages
to negotiate with government authorities.
(Reporting by Jibran Ahmad in Peshawar, writing by Shilpa
Jamkhandikar; editing by Miral Fahmy, Simon Cameron-Moore and
Bernadette Baum)
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