GSK's cancer drug Jemperli meets overall survival goal in late-stage
trial
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[October 30, 2023]
(Reuters) -British drugmaker GSK said on Monday its cancer drug
Jemperli when combined with chemotherapy, met the primary goal of
overall survival in patients with advanced or recurrent endometrial
cancer in a late-stage trial.
Overall survival, defined as the proportion of trial patients on the
drug who were alive compared to those on a placebo, was one of two
primary goals in a Phase III trial, GSK said.
The company said the data showed a statistically significant and
meaningful benefit in the overall patient population, without giving
further details.
Jemperli has been approved in the United States and UK to treat specific
subtypes of advanced or recurrent endometrial cancer in combination with
chemotherapy.
GSK's latest results could open the way for approval in a much wider
group of patients.
The company, which has sought to rebuild its oncology business in recent
years, is expecting a decision on authorization from Europe's regulator
by the end of 2023.
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A robot, Cellular Automated Screening Platform, runs cell-based
screening assays in a lab at the GSK Research and Development centre
in Stevenage, Britain, February 21, 2023. REUTERS/Anna Gordon/File
Photo
Jemperli belongs to class of
medicines called PD-1 inhibitors, that work by increasing the
ability of the body's immune system to help detect and fight tumor
cells.
Endometrial cancer, found in the inner lining of the uterus, is the
most common gynecologic cancer in developed countries, with about
417,000 new cases reported globally every year, according to GSK.
The trial's other goal of progression-free survival (PFS) was met
previously. The term PFS refers to how long a patient lives without
the disease getting worse after treatment.
(Reporting by Eva Mathews in Bengaluru; Editing by Janane
Venkatraman and Barbara Lewis)
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