AstraZeneca's breast cancer drug combination fails in late-stage trial
Send a link to a friend
[June 18, 2024]
(Reuters) - AstraZeneca said on Tuesday its breast cancer drug,
Truqap, in combination with chemotherapy agent, paclitaxel, did not meet
its main goals in a late-stage trial to improve overall survival of
patients with a type of breast cancer.
Triple-negative breast cancer remains one of the most challenging forms
of disease to treat due to the lack of known actionable biomarker
targets, and chemotherapy-based regimens continue to be the mainstay of
treatment, AstraZeneca said.
The trial, known as CAPItello-290, was testing whether the drug
combination improved overall survival in patients with inoperable or
metastatic triple-negative breast cancer versus the older and cheaper
chemotherapy agent, paclitaxel, in combination with a placebo.
The study failed to achieve its goals in both the overall trial
population and in a sub-group of patients with tumors harboring specific
biomarker alterations, the drugmaker said.
[to top of second column]
|
An AstraZeneca logo is pictured in Brussels, Belgium March 4, 2024.
REUTERS/Yves Herman/File Photo
"While we are disappointed in the
CAPItello-290 outcome, these results will further our understanding
of the role of the PI3K/AKT pathway in breast cancer," said Susan
Galbraith, executive vice president, oncology R&D, AstraZeneca.
(Reporting by Yadarisa Shabong in Bengaluru; Editing by Sherry
Jacob-Phillips)
[© 2024 Thomson Reuters. All rights reserved.]This material may not be published,
broadcast, rewritten or redistributed.
Thompson Reuters is solely responsible for this content. |