Uganda begins Ebola vaccine trial after new outbreak kills a nurse and infects 2 other people

[February 04, 2025]  By RODNEY MUHUMUZA

KAMPALA, Uganda (AP) — Ugandan authorities on Monday began a clinical trial of a vaccine against the Sudan strain of Ebola that has killed one person in the outbreak declared last week.

Health workers and others exposed to the Ebola strain are being targeted in the study, which began four days after Uganda announced the death of a nurse in the capital, Kampala. Two more cases were confirmed on Monday in relatives of the first victim.

Officials are investigating the source of the outbreak. Ebola is spread by contact with bodily fluids of an infected person or contaminated materials. Symptoms include fever, vomiting, diarrhea, muscle pain and at times internal and external bleeding.

Responding to this outbreak could prove difficult because Kampala has a highly mobile population of about 4 million. The nurse who died had sought treatment at a hospital just outside the capital and later traveled to Mbale in the country’s east, where he was admitted to a public hospital. Health authorities said he also sought the services of a traditional healer.

At least 234 contacts in this outbreak have been identified, according to the Ministry of Health.

Health authorities have access to more than 2,000 doses of a candidate vaccine against the Sudan strain. IAVI provided the vaccine.

The trial “marks a major milestone in public health emergency response and demonstrates the power of collaboration for global health security,” Matshidiso Moeti, the WHO director for Africa, said in a statement.

People walk outside the Mulago National Hospital in Kampala, Uganda, Thursday, Jan, 30, 2024, where a nurse had died of Ebola. (AP Photo/Hajarah Nalwadda )

This is the first Ebola outbreak since the Trump administration's decision last week to withdraw from the U.N. health agency, and since Trump's order for a freeze on foreign assistance.

Uganda has had multiple Ebola outbreaks, including one in 2000 that killed hundreds. Tracing contacts is key to stemming the spread of Ebola, which manifests as a viral hemorrhagic fever.

A trial vaccine known as rVSV-ZEBOV, used to vaccinate 3,000 people at risk of infection during an outbreak of the Zaire strain of Ebola in eastern Congo between 2018 and 2020, proved effective in containing the spread of the disease there.

The confirmation of Ebola in Uganda is the latest in a series of outbreaks of viral hemorrhagic fevers in the east African region. Tanzania declared an outbreak of the Ebola-like Marburg disease last month, and Rwanda in December announced that its own outbreak of Marburg was over.

Scientists don’t know the natural reservoir of Ebola, but they suspect the first person infected in an outbreak acquired the virus through contact with an infected animal or eating its raw meat.

Ebola was discovered in 1976 in two simultaneous outbreaks in South Sudan and Congo, where it occurred in a village near the Ebola River, after which the disease is named.

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