Pro Picks: Lions-Eagles,
Chiefs-Broncos and Seahawks-Rams highlight a week full of marquee
matchups
[November 13, 2025]
By ROB MAADD
Week 11 is filled with marquee matchups.
The Seattle Seahawks (7-2) and Los Angeles Rams (7-2) face off for
first place in the NFC West.
The Broncos (8-2) take on the nine-time defending division champion
Kansas City Chiefs (5-4) looking to prove the AFC West goes through
Denver.
The reigning Super Bowl champion Philadelphia Eagles (7-2) and
Detroit Lions (6-3) meet in prime time in a potential preview of the
NFC title game.
Pro Picks breaks them down.
PACKERS (5-3-1) at GIANTS (2-8)
Line: Packers minus 7
The Packers have lost two in a row. Jordan Love and the offense have
struggled, scoring just 20 points combined in both games. Interim
coach Mike Kafka coaches his first game for the Giants, who fired
Brian Daboll. Jameis Winston will start because Jaxson Dart is in
the concussion protocol. Micah Parsons could have a big day chasing
him around.
BEST BET: PACKERS: 32-16
CHICAGO (6-3) at MINNESOTA (4-5)
Line: Vikings minus 3
Caleb Williams has led the Bears to three comeback wins in the last
four games and they’ve won six of seven since an 0-2 start under Ben
Johnson. Williams is 1-7 in eight starts vs. NFC North teams,
including a loss to Minnesota in Week 1. J.J. McCarthy led the
Vikings to a comeback win at Chicago in Week 1. He struggled against
Baltimore last week in his fourth career start after an impressive
performance against Detroit.
UPSET SPECIAL: BEARS: 23-22
NEW YORK JETS (2-7) at NEW ENGLAND (8-2)
Line: Patriots minus 13
The Jets have won two in a row, but they’re overmatched against the
streaking Patriots, who’ve won seven straight games. Drake Maye is
playing at an MVP level for New England. The Patriots have won 16 of
their last 18 games against New York.
PATRIOTS: 26-14
WASHINGTON (3-7) at MIAMI (3-7) in Spain
Line: Dolphins minus 2 1/2
It’s a lost season for the Commanders after reaching the NFC title
game last year. Marcus Mariota fills in for Jayden Daniels again.
He’s lost seven straight starts as an underdog. The Dolphins are
coming off an impressive rout over Buffalo. Favorites are 10-5 ATS
in international games when both teams have losing records.
DOLPHINS: 24-20
HOUSTON (4-5) at TENNESSEE (1-8)
Line: Texans minus 6 1/2
Davis Mills saved Houston’s season by leading an improbable comeback
when down 19 in the fourth quarter. He could start again if C.J.
Stroud can’t return from a concussion. The Titans have been
terrible. Cam Ward has thrown only five TD passes. But they’re
coming off a bye, while Houston needed to stage a furious rally to
win.
TEXANS: 20-14
LOS ANGELES CHARGERS (7-3) at JACKSONVILLE (5-4)
Line: Chargers minus 3
The Chargers have won three straight, their defense was dominant
last week and Justin Herbert withstood five sacks behind a depleted
offensive line in a 15-point win against Pittsburgh. The Jaguars
couldn’t protect a 19-point lead against a backup quarterback. They
need to rebound at home. Herbert is 14-22 straight up against teams
with a winning record but 2-1 this season.
CHARGERS: 23-17
CINCINNATI (3-6) at PITTSBURGH (5-4)
Line: Steelers minus 5 1/2
The Bengals have lost two in a row despite scoring 38 points in one
and 42 in the other. Cincinnati’s defense might be just what Aaron
Rodgers needs to get on track after a miserable game against the
Chargers. The Steelers have lost three of four, including a
prime-time game against the Bengals in Week 7. Under Mike Tomlin,
Pittsburgh is 27-11 straight up and 25-12-1 ATS vs. Cincinnati.
STEELERS: 27-20
CAROLINA (5-5) at ATLANTA (3-6)
Line: Falcons minus 3 1/2
The Panthers beat the Packers at Lambeau Field but lost to the
Saints. Their passing game has struggled and questions about Bryce
Young persist. The Falcons have lost four in a row since beating
Buffalo, and Michael Penix Jr. has been inconsistent. Carolina
routed Atlanta 30-0 in Week 3. The Panthers have never won three
consecutive games both straight up and ATS against the Falcons.
FALCONS: 24-16
TAMPA BAY (6-3) at BUFFALO (6-3)
Line: Bills minus 5 1/2
The Buccaneers are missing several injured playmakers on offense and
the defense is susceptible to allowing big plays. It’s possible they
could get running back Bucky Irving back to face the league’s
third-worst run defense. Josh Allen and the Bills are coming off a
stunning lopsided loss to Miami one week after beating Kansas City.
With Baker Mayfield, the Bucs are 13-4 ATS in a game after a loss.
BILLS: 27-23
[to top of second column] |
Kansas City Chiefs quarterback Patrick Mahomes (15) is hit by
Buffalo Bills defensive end Joey Bosa while throwing a pass
intercepted by Bills cornerback Maxwell Hairston during the second
half of an NFL football game Sunday, Nov. 2, 2025, in Orchard Park.
N.Y. (AP Photo/Adrian Kraus)
SAN FRANCISCO (6-4) at ARIZONA (3-6)
Line: 49ers minus 2 1/2
With Mac Jones or Brock Purdy at quarterback, the 49ers have to rely
on their offense featuring Christian McCaffrey and George Kittle
because their defense has been depleted by injuries. Jacoby Brissett
gets another start for the Cardinals. He could target Trey McBride
20 times in this one with Marvin Harrison Jr. out. Niners coach Kyle
Shanahan is 8-9 against Arizona.
49ERS: 27-20
SEATTLE (7-2) at LOS ANGELES RAMS (7-2)
Line: Rams minus 3
Both teams are also 7-2 ATS this season. It’s Sam Darnold’s biggest
game since losing consecutive must-win games last season with
Minnesota, including a playoff loss to the Rams. Seattle is one of
the league’s most well-balanced teams. The Seahawks are 11-1 on the
road under coach Mike Macdonald. Matthew Stafford is having a
spectacular season for the Rams, whose only two losses came on the
final play.
RAMS: 24-20
BALTIMORE (4-5) at CLEVELAND (2-7)
Line: Ravens minus 8
Lamar Jackson is back, the Ravens have won three in a row and
they’re aiming to take over the AFC North from Pittsburgh. But they
have to take care of business against lesser opponents before they
face the Steelers in Week 14. The Browns are sticking with rookie
Dillon Gabriel at QB. Deshaun Watson, if healthy, might get a chance
before Shedeur Sanders. Jackson is 21-5 against Cleveland. The
Browns are 11-22 ATS vs, division opponents under coach Kevin
Stefanski.
RAVENS: 30-13
KANSAS CITY (5-4) at DENVER (8-2)
Line: Chiefs minus 4
Despite being the AFC’s current 8th seed, the Chiefs are favorites
to win the Super Bowl and this week on the road. Patrick Mahomes has
Rashee Rice, Xavier Worthy and Marquise Brown to go along with
Travis Kelce. Denver’s dominant defense presents a tough challenge.
The Broncos have struggled on offense behind Bo Nix’s inconsistency.
The Chiefs are coming off a bye. Coach Andy Reid is 22-4 after a bye
in the regular season, including 6-1 with Mahomes.
CHIEFS: 24-18
DETROIT (6-3) at PHILADELPHIA (7-2)
Line: Eagles minus 2 1/2
Dan Campbell took over play-calling duties for the Lions and the
offense was dynamic again. Jared Goff, Jahmyr Gibbs and Amon-Ra St.
Brown vs. Philadelphia’s talented defense is going to be an
excellent matchup. The Eagles will need their offense to step up
against Detroit. Jalen Hurts has made plays when challenged. A.J.
Brown has to be more involved in the passing game. Saquon Barkley
needs more open lanes. Campbell and Goff are 13-3 in prime-time
games. All three losses came as underdogs.
EAGLES: 27-23
DALLAS (3-5-1) at LAS VEGAS (2-7)
Line: Cowboys minus 3 1/2
It’ll be an emotional night for the Cowboys in their first game
since defensive tackle Marshawn Kneeland died. DT Quinnen Williams
and LB Logan Wilson will make their debut for Dallas. Dak Prescott
is 25-6 in prime-time games and the Cowboys are 18-12-1 ATS in those
games. The Raiders played Denver tough in a 10-7 loss. Ashton Jeanty
could get going against the league’s fifth-worst run defense.
COWBOYS: 27-20
Last week: Straight up: 10-4. Against spread: 8-6.
Overall: Straight up: 106-42-1. Against spread: 77-71-1.
Prime-time: Straight up: 20-14-1. Against spread: 15-20.
Best Bet: Straight up: 8-2. Against spread: 7-3.
Upset Special: Straight up: 7-3. Against spread: 7-3.
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