Hanley Ramirez hit a go-ahead, two-run double off Wagner in the ninth inning and the Florida Marlins rallied past the Mets 4-3 in New York.

Khalil Greene homered and drove in three runs, including the go-ahead run in the 11th in Cincinnati, and San Diego overcame a rare Hoffman failure with a 12-7 win over the Reds.

On a night when Barry Bonds added to his home run record with No. 758 against the Pittsburgh Pirates, two of baseball's top 10 all-time saves leaders couldn't add to their totals. Wagner and Hoffman came in with a combined success rate of 88.8 percent, having saved 861 games in 970 chances.

It was Wagner's second blown save in 28 chances this season. The left-hander escaped a bases-loaded, none-out jam to save a 4-3 victory over Atlanta on Wednesday night. He hadn't allowed a run in 20 outings since June 15.

"Just one of those nights where I didn't make the pitches," Wagner said. "I was trying to go up and in. It was probably more middle. I'm just not locating very well."

Carlos Beltran hit a three-run homer in his return from the disabled list, giving the Mets the 3-2 lead they handed to Wagner (1-1) in the ninth. After entering with a streak of 21 scoreless innings, he couldn't hold it.

"Billy's been outstanding all year. You expect him to close the game," Mets manager Willie Randolph said.

Miguel Olivo hit a leadoff single and pinch-hitter Jason Wood walked with one out. Ramirez, who began the day leading the NL with a .340 batting average, drove a 1-2 pitch over Beltran's head in center field to score both runners. The 2006 NL Rookie of the Year pumped his fist as he pulled into second base.

"I like the pressure moments," Ramirez said. "I was looking for a mistake and I got it."

In other NL games, it was: Philadelphia 5, Atlanta 4; Milwaukee 5, Houston 4, 11 innings; Los Angeles 2, St. Louis 1; Chicago 6, Colorado 2; Arizona 11, Washington 4; and Pittsburgh 8, San Francisco 7.

Hoffman had converted 25 consecutive save opportunities before Brandon Phillips led off the ninth with a double and Scott Hatteberg followed one out later with a double off the left field wall to tie the game at 7. Hoffman came back to get two popups and end the inning, but the blown save was Hoffman's first since April 27 against Los Angeles.

"Those were pretty hard-fought at bats," Greene said about Phillips and Hatteberg. "One thing he's always been able to do is come back and maintain."

David Weathers (2-4), Cincinnati's sixth relief pitcher, walked the bases loaded with one out to set up Greene's sacrifice fly to left field, which snapped a 7-7 tie. Josh Bard followed with a two-run triple down the right field line, and Kevin Kouzmanoff greeted reliever Victor Santos with a first-pitch two-run homer to left.

Weathers left the clubhouse before the media was allowed in, but Reds manager Pete Mackanin said the closer - who had converted 22 of 27 save opportunities - can't be expected to deliver every night.

"He doesn't do that," Mackanin said about Weathers' control problems. "It's just one of those things. It's totally unexpected. That's just the way it goes. You can't expect him to be as good as he's been all year."