Hunter Pence's leadoff single in the fourth, Eric Munson's single to start the sixth and Carlos Lee's one-out single in the seventh were the only hits allowed by Zambrano (11-7). Houston also committed four errors after the four-day break.

After Lee's single, Zambrano walked Mark Loretta and Luke Scott to load the bases before Carlos Marmol relieved and got Munson on a fly to center.

The Astros made two errors on the same play in the fourth when the Cubs scored three runs off Jason Jennings (1-5). Cliff Floyd and Mark DeRosa singled to put runners at the corners before Jacque Jones hit a sacrifice fly to make it 1-0 with DeRosa alertly racing to second on the play.

When Geovany Soto, just called up from Triple-A, hit a grounder to third, Mike Lamb fumbled the ball and then threw low to Lance Berkman at first for an error. DeRosa started around third but then retreated to the bag before Berkman airmailed a throw over the third base dugout and into the stands for another error, allowing DeRosa to score and Soto to take third. Zambrano then dumped an RBI single into left for a 3-0 lead.

Jennings lasted 5 1-3 innings, allowing 10 hits and four runs with one walk and matching a season high with seven strikeouts. He was taken out in the sixth after Zambrano hit his second single and Alfonso Soriano doubled.

After retiring Ryan Theriot on a slow roller, reliever Chad Qualls intentionally walked Derrek Lee to load the bases and then walked Aramis Ramirez to force in a run and make it 4-0.

The Cubs added two runs in the eighth off reliever Matt Albers, who gave up a single to Soriano, walk to Theriot and two-run double to Derrek Lee. Chicago then loaded the bases as Floyd took an intentional walk and DeRosa reached on shortstop Loretta's second error of the game before reliever Trever Miller got the final two outs.

Notes: Zambrano also started the final game before the All-Star break, losing to the Pirates. He's the first Cubs pitcher to make starts in consecutive games in the same season since Jon Leiber nearly six years ago. Leiber started Sept. 10, 2001 and then Sept. 18, 2001 after a league-wide work stoppage caused by the terrorist attacks. ... Jennings got the start because the Astros wanted to give ace Roy Oswalt another day off to recover from travel. Oswalt was on the NL All-Star team in San Francisco, but did not pitch Tuesday night. ... Soriano, who hit a ninth-inning homer in Tuesday night's game, struck out his first three times up Friday before his sixth-inning double.