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Jose Guillen tied it at 2 with a solo homer in the third, and Washburn helped himself with two out in the fourth, when he drove in Kenji Johjima with a single -- his ninth hit in 32 career at-bats -- to make it 3-2.
Rich Hill allowed three runs and eight hits in 6 2-3 innings for the Cubs. He struck out four and walked one.
Chicago used five relievers and the Mariners six.
The Cubs were so strapped for pinch hitters that Carlos Zambrano, who homered and got the win Monday against Houston, batted for reliever Bob Howry with two out in the 11th. The crowd greeted him with a roar, then groaned as he struck out.
DeRosa had three hits for Chicago, and Lee added two after going 4-for-31 in his previous eight games.
Johjima had three hits for Seattle, which looked like it was ready to be blown out early on.
Washburn threw 29 pitches in the first inning alone -- certainly not what he had in mind after two rough starts against Texas and Baltimore.
This one started with a leadoff walk to Soriano, and in a flash, the Cubs were ahead 2-0. The next batter, Angel Pagan, doubled to the warning track in left-center to drive in the first run and came around when Lee lined a single to left.
Notes: The Mariners dropped two of three against the Cubs in Seattle in June 2002. ... Manager Mike Hargrove said RHP Mark Lowe, on the 60-day DL following surgery on his right elbow, will throw two more bullpen sessions and one or two simulated games before beginning a minor league rehab stint next week.
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