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It was Detroit's second straight win over the A.L. Central leaders.
Verlander (3-9) didn't walk a batter and struck out three. He threw 101 pitches in his best outing of the season.
White Sox starter Javier Vazquez (6-5) gave up five runs and 10 hits in six innings, walking three and striking out nine.
Thames' three-run homer in the second gave Detroit a 3-0 lead. Magglio Ordonez's two-out, run-scoring single in the fourth made it 4-1 and Carlos Guillen tripled in a run in the sixth.
Miguel Cabrera walked to lead off the Detroit second. One out later, Edgar Renteria's infield single sent him to second. Thames then drilled Vazquez's first pitch over the left-field fence for his seventh home run.
Chicago made it 3-1 in the fourth on A.J. Pierzynski's RBI single. Orlando Cabrera led off the inning with the White Sox's first hit of the game, a grounds-rule double down the third base line. Pierzynski followed with a looping liner down the right-field line to score Cabrera, but was thrown out at second trying for a double.
[Associated Press]
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