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St. Louis reliever Mike Parisi (0-4) gave up a leadoff single to Curtis Granderson and intentionally walked Carlos Guillen and Miguel Cabrera before Thomas drew his second run-scoring walk of the day.
Pujols, in his first game back from the disabled list, hit an RBI single in the ninth to give the Cardinals the lead. But Gary Sheffield, who returned Tuesday from the disabled list, answered with a solo homer for Detroit in the bottom of the inning.
Pujols, who missed 13 games with a calf injury, was 4-for-4 with an intentional walk.
Reliever Bobby Seay (1-1) worked the 10th for the win.
Detroit scored the game's first run when Cardinals reliever Rod Villone surrendered a bases-loaded walk to Thomas in the bottom of the sixth, but St. Louis answered in the seventh when Brendan Ryan came home on a fielding error.
Detroit starter Nate Robertson, seeking his fourth victory in as many starts, surrendered 11 hits but stranded eight St. Louis runners in 6 1-3 innings. His counterpart, Cardinals right-hander Todd Wellemeyer, pitched the first four innings before giving way to Villone.
Tigers second baseman Placido Polanco was ejected by umpire Paul Schrieber in the sixth for arguing a called third strike.
The Tigers are 14-5 and have won five straight series since Oakland completed a three-game sweep on June 4.
Notes: The Cardinals placed LHP Randy Flores on the 15-day disabled list with left ankle tendinitis. His departure leaves the club with just one left-hander
-- reliever Rod Villone. ... Curtis Granderson extended his hitting streak to a career-best 14 games for the Tigers. ... Detroit C Dane Sardinha, called up from Triple-A Toledo on Wednesday, made his Tigers debut behind the plate. ... St. Louis is 1-5 against the Tigers since defeating them in the 2006 World Series. The teams will meet again next season in interleague play.
[Associated Press]
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