It's the type of defeat that might destroy some teams. But the Rays have been resilient all year and believe they have the makeup to rebound after not completing the job at Fenway Park on Friday night.
"I know where we've come from, where we are right now, and I have total faith that we're going to finish this thing off," manager Joe Maddon said, reflecting on Boston's 8-7 win in Game 5.
"It's about one moment at a time. We lost that game. That's over with. There's nothing we can do about that, and there's nothing constructive we can take out of that, except I thought we played really well. I think that's being overlooked."
Despite blowing a 7-0 lead over the final three innings, the Rays won two of three at Fenway and are up in the series, three games to two.
Now, they've got two cracks at winning the pennant at Tropicana Field, where they compiled the best home record in baseball this season.
Shields, whose nickname is Big Game, will pitch Game 6 Saturday night against Josh Beckett, Boston's struggling postseason ace who was lit up by Tampa Bay's suddenly potent offense in Game 2.
"That was a tough loss. It was disappointing, but I woke up this morning feeling pretty good," Shields said.
"When it comes down to it, they have more pressure than we do. They're the defending champions. We're a team that finished in last place last year."
Even before the Rays left Fenway for the airport and a long flight that landed in Florida in the wee hours of the morning, Maddon had a good feeling about the way his players were handling the loss.
The Rays were seven outs from their first trip to the World Series before a seemingly comfortable lead slipped away.
The Red Sox rallied from a 3-0 deficit to beat the New York Yankees in the 2004 ALCS and were down 3-1 to Cleveland before coming back to win last year's ALCS. Both times they went on to win the World Series.
"You don't want to get to the situation where you are 1-and-3," Red Sox slugger David Ortiz said. "But you get to it, you've got to keep on trying. You've got to bring everything you've got into it and we have."
The Rays are undaunted by history. They've see no reason why they won't play well in Game 6 and, if necessary, Game 7 Sunday night, when right-hander Matt Garza would pitch against Boston lefty Jon Lester.
"I would be surprised if there's any hangover," Maddon said, adding that he had not spoken with the players about putting Thursday behind them.
"For me to draw attention to it, I don't like to do that. I think sometimes in an attempt to help, you can actually make things worse. I really believe that. ... Baseball players a lot of times have their own mechanism to deal with things."
The Red Sox realize they still have a steep hill to climb, considering they lost eight of nine at Tropicana Field during the regular season and split the first two games of the ALCS here.
But they also believe there just as much pressure on the Rays.