The 6-foot-10 sophomore has been out since sustaining the concussion during the first half of a loss at Texas on Saturday. He sat out as No. 3 Oklahoma lost 87-78 at home to No. 15 Kansas on Monday.
The Sooners visit Texas Tech on Saturday. Coach Jeff Capel says team physician Brock Schnebel cleared Griffin to play against the Red Raiders.
Griffin is averaging 22 points and 13.8 rebounds, second best in Division I. He also ranks second nationally with 22 double-doubles.