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Micah Hoffpauir had a three-run homer for the Cubs and Zambrano (5-4) allowed three runs and five hits.
St. Louis starter Kyle Lohse (4-5), who was activated from the 15-day disabled list before the game, struggled in his first appearance since leaving an outing against Cincinnati on June 3 because of a strained right forearm.
"Hoffpauir's first pitch (was) a curve," said Lohse, who allowed four runs and eight hits in five innings. "It wasn't a bad pitch but he jumped all over it. As the game went on I pitched pretty well."
St. Louis rallied to tie it at 3 but Zambrano hit a solo drive in the fourth to give the Cubs the lead again.
"He swings a big bat. He can hit," Theriot said. "It's no surprise. I think everybody knows if they throw one way where he is swinging, he is going to hurt you."
Zambrano settled down after a slow start, striking out six of the last 10 hitters he faced. He finished with seven Ks and two walks.
NOTES: In the fifth inning of Game 2, with Wainwright at first base, Ryan hit into what appeared to be a doubleplay, but Wainwright deflected the ball with his right hand on the turn by Theriot. Wainwright did not show any signs of an injury to his hand. ... Cardinals third base coach Jose Oquendo missed the doubleheader to manage the World Team in the Futures Game in St. Louis. Joe Pettini took his place at third.
Copyright 2009 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
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