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Glen Davis started at forward in place of Powe after missing the previous four games with a sprained right ankle.
Boston led 34-21 after one quarter but quickly lost control as Miami opened the second period with an 10-2 run that cut the margin to 36-31. The Celtics stretched that to 45-37 before the Heat made an even stronger surge, ending the half with a 17-4 spurt and a 54-49 lead.
The run began with a free throw by Jermaine O'Neal, who had seven of the 17 points, and ended with a layup by Chalmers.
Daequan Cook, starting in place of Wade, gave Miami its first lead, 46-45, on a 3-pointer.
Pierce had 12 points in the first quarter when he hit 5-of-6 shots but was scoreless in the second when he missed all three of his attempts.
Notes: Boston big men Davis and Mikki Moore each picked up his fourth foul in the final minute of the first half. Both fouled out in the fourth quarter. ... Cook made his second start of the season.
[Associated Press;
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