Lee, the reigning AL Cy Young Award winner, struck out five and had no walks in his first career playoff start. He retired 16 straight batters at one point until Garrett Atkins hit a wind-blown double in the seventh. Lee lost his shutout when Troy Tulowitzki doubled in a run with two outs in the ninth.
Game 2 of the best-of-five NL division series is set for Thursday with Cole Hamels, last year's World Series and NLCS MVP, on the mound for the Phillies against Colorado's Aaron Cook.
Some questioned manager Charlie Manuel's decision to give Lee the ball over the playoff-tested Hamels for the first game. But Lee made his manager look brilliant with a masterful performance.
On a day when swirling winds made flyballs an adventure, Lee ignored the elements and shut down the NL's second-highest scoring offense. Avoiding the adventures that come with the Phillies bullpen, Lee mixed a deceptive fastball with off-speed pitches, had pinpoint accuracy and threw 113 pitches.
The hard-throwing Jimenez was equally impressive against the league's No. 1-scoring offense for four innings, but ran out of gas in the fifth. He got chased with no outs in the sixth after allowing nine hits and five runs in five-plus innings.
A sellout crowd of 46,452 -- the largest in the six-year history of Citizens Bank Park
-- rocked the ballpark, waving their white-and-red "Fightin' Phils" rally towels. The Phillies were 7-0 at home last October and set a franchise attendance record this season.
Werth, one of five All-Stars in Philadelphia's lineup, got it started with a walk in the fifth. He scored when Ibanez ripped a double into the right-field corner. Ibanez's hit fired up the raucous crowd, which screamed "Rauuuuuuuul!" Carlos Ruiz followed with a single to right to make it 2-0.
The Phillies got insurance runs in the sixth. Chase Utley led off with a single and stole second. Howard lined a run-scoring double to left that mixed up Carlos Gonzalez, who fell backward into the wall.
Werth followed with a drive that hit high off the left-center field wall. Werth may have had a chance for an inside-the-park homer, but he trotted slowly to first before turning it on and settling for a triple after the wind kept the ball in the park.
Joe Beimel came in to face Ibanez, who singled in another run to make it 5-0.