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Andres Blanco led off the fourth with a double and Lee followed with his 27th homer of the year. Lee, who after a slow start is batting .322 with 24 homers in 92 games since May 19, reached the 90 RBI mark for the fifth time in his career.
"He just left a fastball over the middle for me," Lee said.
The Cubs went 11-6 against the Astros this year, matching their most victories over Houston in one season.
The Astros ended a nine-game road trip with only two victories, making it their worst multi-series trip this season. Like the Cubs, they have slumped badly the last month to fall well behind St. Louis in the NL Central.
NOTES: Even though Astros CF Michael Bourn has reached base in 25 straight games, the longest active streak in the majors, he was given the day off. "I really didn't want to do it," manager Cecil Cooper said. "Michael's probably the MVP of our team. I'm aware of (the streak), but I need to play some of these other guys, and he's 1 for 8 against (Lilly)." Jason Michaels played CF and went 0 for 3. ... The Cubs activated RHP David Patton from the DL, giving them 29 players on their active roster.
Copyright 2009 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
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