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Mayo had a last-second opportunity to win it for the Grizzlies, but his long jumper bounced off the rim as the buzzer sounded.
Absent from the Lakers lineup for his longest stretch in five years, Bryant scored nine points in the opening quarter, including a four-point play, and triggered a late first-quarter run with two breakaway dunks to increase the Lakers lead to 11.
Bryant last played Feb. 5 and Los Angeles went 4-1 without him.
The Grizzlies took their first lead early in the third quarter on a 3-pointer by Mayo for a 59-56 advantage and didn't trail again until Bryant's game-winning shot.
Bryant, averaging 42.5 points against Memphis in two previous games this season, began his late nine-point run with a jumper from the left wing with 2:23 to go to trim the Memphis lead to 95-92.
With Bryant scoring 17 of his points in the first half, the Lakers built several 14-point leads before settling for a 53-48 halftime advantage.
"We gave ourselves an opportunity to win the game," Hollins said. "But Kobe was better. That's the bottom line."
NOTES: Grizzlies forward Zach Randolph broke Pau Gasol's single-season franchise record for offensive rebounds (238). Playing in his 56th game of the season, Randolph grabbed four offensive rebounds to increase his total to 242. Gasol played for Memphis from 2001 and 2008. . . . The game attracted the third sellout (18,119) to the FedExForum this season.
Copyright 2010 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
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