"My mind came off the game, of course," Jerebko said. "I don't know if it changed the outcome."
Prince had 23 points and Richard Hamilton added 20 for Detroit, which lost its sixth straight. The Pistons will head home to face Houston on Sunday. It's not known when Stuckey will rejoin them.
Antawn Jamison's 3-pointer to open the fourth gave Cleveland its first lead of the night. Jamison scored the game's next five points, finishing with 17, as the Cavaliers took control. Anderson Varejao also had 16 points and 10 rebounds off the bench for Cleveland, which won its fifth straight over the Pistons.
James said he was watching a documentary Thursday on the 20th anniversary of the death of Loyola Marymount star Hank Gathers, who died of a heart attack during a game in 1990.
"That's the first thing I thought of," James said. "I was just hoping, of course, that wasn't the case. I'm happy Rodney's doing OK. I know a lot of guys on that team. I know Ben (Wallace), of course. I've known Rip (Hamilton) and Tay (Prince)."
James had a huge block on Hamilton in the game's opening minutes, swatting the shot into the first few rows behind the basket. He later triggered a first-half rally with a steal and dunk from a step inside the free-throw line.
Kwame Brown's jumper with 7:46 left in the second quarter put Detroit up 49-28, but the Pistons made just three baskets the rest of the quarter as Cleveland began mounting its comeback.
It was the first time Cleveland rallied from such a large deficit since Nov. 11, 2006, when it rallied from a 25-point deficit to beat Boston.
Fans attending the game Friday set a world record for wearing a Snuggie for five minutes, becoming the largest gathering of people to wear fleece blankets.
"The Snuggies might have been part of the reason we were so comfortable and so lackadaisical to start the game," James said. "You feel like you're getting ready for bed. We might need to have Boot Night one day so we're ready for combat. No more Snuggie Nights."
NOTES: James became the franchise's career leader in minutes played, surpassing Zydrunas Ilgauskas, who became the franchise leader earlier this season. ... Daniel Gibson remains away from the team. Singer Keyshia Cole, who is engaged to Gibson, gave birth to their son Tuesday. ... Delonte West was back on the floor after being inactive Wednesday at New Jersey. ... Wallace (right knee) missed his second straight game.