Canseco posted on the social networking site that the FBI was about to visit his house, then said he had received a subpoena to appear before the grand jury "about roger clemens,andrew pettite and others" on April 8.
Pettitte has acknowledged taking human growth hormone and told congressional investigators that Clemens informed him a decade ago that he used HGH.
"Its like the godfather," Canseco said in a later post, "when I thought I was out they drag me back in. And now it begins again."
Prosecutors have asked a federal grand jury in Washington to decide whether to indict Clemens for lying under oath to Congress in 2008 when the seven-time Cy Young Award winner denied using steroids or HGH.
In Canseco's 2005 book, "Juiced: Wild Times, Rampant 'Roids, Smash Hits, and How Baseball Got Big," the slugger claimed he introduced several players to steroids and performance-enhancing drugs. But Canseco has said he has no knowledge of Clemens using drugs.
"I have never had a conversation with Clemens in which he expressed any interest in using steroids or human growth hormone," Canseco said in a 2008 affidavit submitted to the same congressional committee that heard his former teammate's testimony. "Clemens has never asked me to give him steroids or human growth hormone, and I have never seen Clemens use, possess or ask for steroids or human growth hormone."
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