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Meche was replaced by Hughes to start the seventh after allowing one run on four hits.
Buehrle was just as good, for a while.
Working quickly and throwing strikes, the left-hander didn't allow a baserunner until Guillen flared a single to right with one out in the fifth.
Then Buehrle's night came apart.
Betancourt started it in the sixth inning, hitting the first pitch he saw out to left for a solo homer that tied it at 1-all.
Guillen hurt Buehrle again in the seventh by fisting a run-scoring single into center, then Maier got Kansas City's fifth straight hit, a two-run single that chased Buehrle.
Jason Kendall added a run-scoring single off Tony Pena and another run came in on Teahen's fielding error to cap an inning that included 11 Kansas City hitters and four White Sox pitchers.
Buehrle allowed six runs -- five earned -- on eight hits in six innings.
NOTES: White Sox RF Carlos Quentin was scratched from the lineup due to a stomach virus. Mark Kotsay played in his spot after manager Ozzie Guillen held Andruw Jones out with a stiff neck. ... Royals RHP Josh Rupe accepted his outright assignment to Triple-A Omaha and will report to the team on Saturday. ... Teahen was 0 for 4 in his first trip back to Kauffman Stadium since being traded in the offseason.
[Associated Press;
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