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 James Russell (1-3) gave up four runs, five hits and four walks in four innings.
Ty Wigginton had three hits for Colorado, including a homer and a double. Troy Tulowitzki added two hits and an RBI double in the third.
At 16-7, the Rockies have the best 23-game start in team history.
Helton's homer to right field in the first inning landed only a few rows behind the ivy, aided by the wind. In the fifth, though, he hit a long no-doubter out to center.
It was the 27th career multihomer game for Helton and his first since Aug. 7, 2007. against Milwaukee.
Tulowitzki let a grounder by Geovany Soto skip under his glove, letting the Cubs take a 2-1 lead in the first. Earlier, Jeff Baker hit a two-out single to tie it.
NOTES: One night after his first career five-hit game, Chicago's Kosuke Fukudome was out of the starting lineup with the Cubs facing LHP De La Rosa. Manager Mike Quade said Fukudome would be seeing plenty of action in the days ahead with the Cubs facing a string of right-handed starters at Arizona and Los Angeles. Fukudome grounded out twice after entering as a pinch-hitter in the seventh, snapping his hitting streak at eight games. ... Rockies starter Aaron Cook is getting closer to returning to the rotation. Cook threw 60 pitches during a bullpen session on Monday, reporting no problems. Manager Jim Tracy said the broken finger on Cook's right hand is "no longer an issue" and that he is now in a spring training mode. Cook will throw again on Saturday and if all goes well, he'll rejoin the Rockies next week in Arizona to continue his throwing program. ... Tracy gave OF Carlos Gonzalez the night off on Tuesday to "let him clear his head." Gonzalez, who is hitting .217 and is just 1 of 20 against lefthanders this season, finished third in the NL MVP voting last season. Gonzalez entered the game as a defensive replacement in the eighth and grounded out in the ninth. ... Rockies catcher Chris Iannetta stole his second base in 363 career games in the fourth inning.
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