Bynum, who turned in a similarly strong performance when the Lakers beat the 76ers last month, shot 6-for-8 from the floor and 5-of-6 from the foul line this time. He also blocked three shots.
Derek Fisher added 17 points for Los Angeles, and Ronny Turiaf, starting because Lamar Odom was serving a one-game suspension, had 15 points and five blocked shots. Kobe Bryant, content to let his teammates do the scoring, took only nine shots and scored 15 points.
Lakers reserves got a lot of playing time because Los Angeles opened a lopsided lead in the second quarter and wasn't threatened afterward. Rookie Javaris Crittenton scored a career-high 19, and Jordan Farmar finished with 16 points.
The game was the fifth of a six-game trip for the 76ers, who looked weary. The Lakers outshot them 66 percent to 42 percent from the floor.
Louis Williams led Philadelphia with 17 points. Fellow reserve Thaddeus Young had 16, and Andre Iguodala 15.
Bynum scored 27 points and pulled down 11 rebounds in the Lakers' 106-101 win at Philadelphia on Dec. 21.
The Lakers were coming off a 110-91 loss to Boston on Sunday that was their worst home defeat of the season. But they have won five of six overall and 11 of 14.
Los Angeles opened a 61-36 lead on Fisher's 3-pointer 1:53 before halftime, and the Lakers were up 62-40 at the break. Los Angeles extended the lead to as many as 34 points in the third quarter, and reserves played most of the fourth for both teams.
