Brandon Roy led Portland (30-19) with 32 points, nine rebounds and six assists. The Trail Blazers, who had outrebounded their last six opponents, didn't do so against the Thunder, with Oklahoma City holding a 43-37 advantage.
Nick Collison and Earl Watson each had a double-double for the Thunder. Collison finished with 21 points and 13 rebounds while Watson came off the bench to record 12 points and 11 assists, the sixth time this season he'd reached double digits in assists.
After trailing by 22 points, the Trail Blazers rallied in the final minutes but came no closer than eight points late in the fourth quarter.
Oden, a center out of Ohio State taken first overall by Portland in the 2007 draft, and Durant, a guard out of Texas taken second by the Seattle SuperSonics, had met only once previously, in the 2006 McDonald's All-American high school game.
Friday was a mismatch, and not only because the two play different positions. Durant scored 30-plus points for the 12th time this season and for the third straight game, the first time he'd done that in his pro career. He finished 12 of 25 from the field and had three rebounds.
Meanwhile, Oden struggled. He started Friday leading NBA rookies in double-doubles with 14, but he played only 12 minutes in the first half, failing to take a shot and grabbing just two rebounds. He didn't score until making two free throws in the opening minute of the second half, and his first basket
- a powerful dunk - didn't come until 8:33 remained in the third quarter.
He quickly picked up his third and fourth fouls while defending Oklahoma City's Nick Collison and went to the bench for good a minute later. Oden finished with four points and two rebounds.
Jeff Green added 20 points for the Thunder, who shot 50 percent from the field. Travis Outlaw scored 20 and LaMarcus Aldridge added 18 for the Trail Blazers.
Oklahoma City shot 58.5 percent from the field in the first half and led by as many as 21 points before settling for a 60-40 halftime lead.
A 7-0 first-quarter run by the Thunder put them ahead 21-14 and they gradually extended their advantage from there, matching their season high in first-quarter scoring with 37 points.
The game was delayed 10 minutes in the third quarter after a dunk by Green dislodged part of the net. Green's dunk put Oklahoma City ahead 81-59 with 2:50 left, matching the Thunder's largest lead to that point.
