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Pettigrew's 3-pointer put the Hilltoppers up 49-34 early in the second half.
Illinois closed to within 50-41 on Dominique Keller's jumper, but Sergio Kerusch and Jeremy Evans answered for Western Kentucky with a pair of statement-making dunks.
Mendez-Valdez made a 21-foot fadeway to stretch the lead to 61-46 midway through the second half. The Hilltoppers led by as many as 17 points.
After Kerusch scored to make it 70-55 late, Illinois guard Brock rolled his eyes, and looked to the scoreboard before heading sheepishly back down the floor.
The Illini were clearly affected by the loss of Frazier. The unquestioned leader of the team and one of the best defenders in the Big Ten injured his hand in practice last week and had surgery on Thursday.
After he missed the conference tournament -- Illinois beat Michigan but fell to eventual champion Purdue -- there was some speculation that Frazier might play in Portland, but coach Bruce Weber ruled him out on Wednesday.
Illinois was making its ninth NCAA tournament appearance in the past 10 years.
[Associated Press;
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