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Ian Desmond homered off Dillon Gee (0-1) leading off the game, and Jayson Werth had four of the Nationals' 13 hits. Werth began the season in a 1-for-14 rut.
"I feel like I've swung the bat pretty good since the middle of January with nothing to show for it," Werth said. "It's not how you start, it's how you finish."
After Desmond's early homer, Werth's RBI single made it 2-0 in the sixth. Bobby Parnell relieved with two on, and Murphy booted a grounder at second base as Werth scored. Wilson Ramos added a run-scoring double.
Gee, who led the Mets with 13 wins last season, allowed four runs -- three earned -- and eight hits in 5 1-3 innings. He struck out six and walked one.
"Thought he threw the ball good," Collins said. "If we make some plays behind him he leaves with a good outing."
Justin Turner hit an RBI single in the seventh for New York, and Cedeno doubled in a run in the eighth.
Washington third baseman Ryan Zimmerman got his 500th RBI with a sacrifice fly in the eighth.
NOTES: Nationals reliever Brad Lidge appeared to take a grounder off his leg in the ninth inning. He remained in the game after a visit from a trainer. ... Ike Davis pinch-hit for the Mets with two on and two outs in the seventh and struck out. New York's usual first baseman is also expected to sit against Strasburg on Wednesday. ... Strasburg will go against LHP Johan Santana (0-0), who made his first big league appearance since 2010 in the Mets' 1-0 win against Atlanta on opening day. ... Former Mets 2B Edgardo Alfonzo threw out the ceremonial first pitch. ... The sparse crowd on a cold, blustery night was announced at 26,927.
[Associated Press;
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